某市结核病涂阳患者耐药情况的调查分析

目的了解并研究广东省惠州市辖区内结核病对一线抗结核药物的耐药情况,为今后惠州市结核病控制工作提供参考依据。方法对2003~2012在惠州市结核病防治研究所结核科门诊就诊的肺结核痰涂片阳性患者进行结核菌培养及药敏试验。结果总体耐药率为50.60%、初始耐药率为42.31%,获得性耐药率为56.85%。耐多药(MDR)率为22.09%。结论惠州地区结核分枝杆菌总耐药率和耐多药率均高于全国平均水平。需更严格执行结核病控制策略,防止耐药患者及耐药菌株的产生和传播。

Analysis on Drug Resistant of Smear-positive Pulmonary Tuberculosis in A City

Objective To understand the levels of drug resistance and for the firstline anti-tubeculoais drugs for 2008-2012 in Huizhou city, and to provide evidence for tuberculosis control. Methods Smear-positive pulmonary tuberculosis were cultured with improved L-J medium and anti-tuberculosis drugs for Department of Tuberculous Diseases TB Prevention and Control Research Institute in Huizhou. Results The total drug resistance rate was 50.60%, the initial and the acquired drug resistance rate was 42.31% and 56.85% respectively, and the multi-drug resistance rate was 22.09%. Conclusion The total mycobacterium tuberculosis drug resistance rate and the MDR rate in Huizhou city are above the national average level. Strategies should be stringently taken to prevent and treat patients with drug resistance pulmonary tuberculosis.