| 胃旁路术对非肥胖2型糖尿病GK大鼠的降糖作用 |
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| 引用本文： | 刘赵琪,翁山耕,石铮,吴书清,孙颖. 胃旁路术对非肥胖2型糖尿病GK大鼠的降糖作用[J]. 实用医学杂志, 2010, 26(5). DOI: 10.3969/j.issn.1006-5725.2010.05.014 |
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| 作者姓名： | 刘赵琪 翁山耕 石铮 吴书清 孙颖 |
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| 作者单位： | 福建医科大学附属第一医院,福州市,350000 |
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| 摘 要： | 目的:观察胃旁路术(gastric bypass,GBP)对非肥胖型2型糖尿病GK大鼠(Goto-Kakizaki rats)的降糖作用及其机制.方法:雄性GK大鼠和SD大鼠各20只,随机分为GK手术组、GK假手术组、SD手术组、SD假手术组,每组10只.测定术前及术后第1、2、4、8周各组体重、空腹血糖(FPG)、糖耐量(OGTT)、血浆胰岛素(INS)、血浆胰高血糖素样肽-1(GLP-1)水平.结果:术后8周,GK手术组FPG和OGTT由术前的(5.0500±0.395)mmol/L和(22.790 0±3.525)mmol/L下降到(4.012 5±0.476)mmol/L和(12.487 5 ±1.173)mmol/L,血浆INS和GLP-1由术前的(674.00±224.372)pg/mL和(6 915.00±1 566.860)pg/mL上升到(873.63±115.920)pg/mL 和(8 508.75±1 247.013)pg/mL,差异均有显著性(P<0.05).结论:GBP能显著改善非肥胖型2型糖尿病GK大鼠糖代谢,与术后肠胰岛轴改变血浆INS、GLP-1水平升高有关.
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| 关 键 词： | 糖尿病,2型 胃旁路术 肠胰岛轴 GK大鼠 |
The antidiabetic effect of gastric bypass surgery in a non-obese type 2 diabetes rat model |
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| LIU Zhao-qi,WENG Shan-geng,SHI Zheng,WU Shu-qing,SUN Yin. The antidiabetic effect of gastric bypass surgery in a non-obese type 2 diabetes rat model[J]. The Journal of Practical Medicine, 2010, 26(5). DOI: 10.3969/j.issn.1006-5725.2010.05.014 |
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| Authors: | LIU Zhao-qi WENG Shan-geng SHI Zheng WU Shu-qing SUN Yin |
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| Affiliation: | LIU Zhao-qi,WENG Shan-geng,SHI Zheng,WU Shu-qing,SUN Yin.The 1st Affiliated Hospital of Fujian Medical University,Fuzhou 350000,China |
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| Abstract: | Objective To investigate the antidiabetic effect and potent mechanism of gastric bypass(GBP) surgery in non-obese type 2 diabetes Goto-Kakizaki(GK) rats.Methods Male rats(20 GK mice and 20 SD mice) were randomized into 4 groups:group1,GK operation,group 2,GK sham operation,group 3,SD operation and group4,SD sham operation.Body weight,fasting plasma glucose,oral glucose tolerance(OGTT),plasma insulin level and glucagonlike peptide-1 level(GLP-1) were determined before surgery and 1,2,4 and 8 weeks after surg... |
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| Keywords: | Diabetes mellitus type 2 Gastric bypass Enteroinsular axis Goto-Kakizaki rats |
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