|
|||||
|
|
| Valproic acid therapy decreases serum 25-hydroxyvitamin D level in female infants and toddlers with epilepsy-a pilot longitudinal study | |
| 引用本文： | Jinchun Qiu,Hongli Guo,Ling Li,Zeyue Xu,Zejun Xu,Xia Jing,Yahui Hu,Xiaoyi Wen,Feng Chen,Xiaopeng Lu. Valproic acid therapy decreases serum 25-hydroxyvitamin D level in female infants and toddlers with epilepsy-a pilot longitudinal study[J]. 生物医学研究杂志, 2021, 35(1): 61-67. DOI: 10.7555/JBR.34.20200057 |
| 作者姓名： | Jinchun Qiu Hongli Guo Ling Li Zeyue Xu Zejun Xu Xia Jing Yahui Hu Xiaoyi Wen Feng Chen Xiaopeng Lu |
| 作者单位： | Department of Pharmacy;School of Basic Medicine and Clinical Pharmacy;Department of Neurology |
| 基金项目： | supported by the Specially Appointed Medical Expert Project of Jiangsu Commission of Health(2019),Wu Jieping Medical Foundation(No.320.6750.2020-04-38);National Natural Science Foundation of China(No.81800530);Natural Science Foundation of Jiangsu Province(No.BK20170149);Hospital Pharmacy Foundation of Nanjing Pharmaceutical Association(No.2019 YX003);Scientific Research Foundation for Young Scholars at the Children’s Hospital of Nanjing Medical University。 |
| 摘 要： | To evaluate if valproic acid(VPA)therapy is associated with vitamin D deficiency among infants and toddlers with epilepsy,a cross-sectional clinical study was conducted in 25 children with epilepsy taking VPA.Blood levels of calcium,phosphorus,alkaline phosphatase,and 25-hydroxy vitamin D[25(OH)D]and plasma VPA level were measured at 1-to 3-month intervals.At the initial and final measurements,vitamin D deficiency or insufficiency was recognized in 8(32%)and 12(42%),respectively.In girls,a decreasing trend in serum25(OH)D levels(P<0.05)was observed.Polytherapy had a significant negative effect on the longitudinal change of 25(OH)D(P<0.05)in girls.In conclusion,our study indicates that a high proportion of girls after VPA therapy had hypovitaminosis D. |
| 关 键 词： | valproic acid vitamin D hypovitaminosis D EPILEPSY infants and toddlers |
Valproic acid therapy decreases serum 25-hydroxyvitamin D level in female infants and toddlers with epilepsy— a pilot longitudinal study |
|
| Qiu Jinchun,Guo Hongli,Li Ling,Xu Zeyue,Xu Zejun,Jing Xia,Hu Yahui,Wen Xiaoyi,Chen Feng,Lu Xiaopeng. Valproic acid therapy decreases serum 25-hydroxyvitamin D level in female infants and toddlers with epilepsy— a pilot longitudinal study[J]. Journal of biomedical research, 2021, 35(1): 61-67. DOI: 10.7555/JBR.34.20200057 | |
| Authors: | Qiu Jinchun Guo Hongli Li Ling Xu Zeyue Xu Zejun Jing Xia Hu Yahui Wen Xiaoyi Chen Feng Lu Xiaopeng |
| Affiliation: | Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China;Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China;School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, China;Department of Neurology, Children's Hospital of Nanjing Medical University, Naning, Jiangsu 210008, China |
| Abstract: | To evaluate if valproic acid (VPA) therapy is associated with vitamin D deficiency among infants and toddlers with epilepsy, a cross-sectional clinical study was conducted in 25 children with epilepsy taking VPA. Blood levels of calcium, phosphorus, alkaline phosphatase, and 25-hydroxy vitamin D [25(OH)D] and plasma VPA level were measured at 1- to 3-month intervals. At the initial and final measurements, vitamin D deficiency or insufficiency was recognized in 8 (32%) and 12 (42%), respectively. In girls, a decreasing trend in serum 25(OH)D levels (P<0.05) was observed. Polytherapy had a significant negative effect on the longitudinal change of 25(OH)D (P<0.05) in girls. In conclusion, our study indicates that a high proportion of girls after VPA therapy had hypovitaminosis D. |
| Keywords: | valproic acid vitamin D hypovitaminosis D epilepsy infants and toddlers |
| 本文献已被 维普 万方数据 等数据库收录！ | |
| 点击此处可从《生物医学研究杂志》浏览原始摘要信息 | |
| 点击此处可从《生物医学研究杂志》下载免费的PDF全文 | |