PCT、白蛋白及IL-6水平检测在早产儿感染中的应用价值

目的 探讨降钙素原(PCT)、白蛋白(Alb)、白细胞介素(IL)-6水平在早产儿细菌感染中的诊断价值。 方法 选择2015年1月-2016年4月在杭州市妇产科医院64例细菌感染早产儿病例为感染组,同期无感染早产儿64例为无感染组。比较2组早产儿血清PCT、Alb、IL-6水平,评价PCT、Alb、IL-6诊断早产儿细菌感染的灵敏度和特异度。 结果 感染组PCT、IL-6水平为(5.27±1.24) ng/L、(224.27±56.54) ng/L,明显高于非感染组的(0.66±0.29) ng/L、(85.31±12.13)ng/L(P<0.05);感染组Alb水平为(24.97±6.27) g/L,明显低于非感染组的(28.31±5.31) g/L(P<0.05)。感染组治疗后PCT、IL-6水平显著下降至(0.54±0.34) ng/L、(82.47±13.84) ng/L(P<0.05),Alb水平显著升高至(29.45±5.83)g/L(P<0.05)。PCT+Alb+IL-6联合诊断的灵敏度和特异度均显著高于单一指标(P<0.05)。 结论 PCT、Alb、IL-6可作为早产儿感染的临床诊断指标,3项指标联合的效果最佳,也可以作为预后疗效评估的有效指标。 

Role of procalcitonin,albumin and interleukin-6 levels in diagnosis of infections in preterm infants

Objective To investigate the diagnostic value of procalcitonin (PCT),albumin (Alb) and interleukin (IL)-6levels for infections in preterm infants. Methods Total 64 cases of infections in preterm infants in neonatal intensive care unit of Department of Neonatology,Hangzhou Women's Hospital between January,2015 and April,2016 were selected as infection group,and 64 cases of non-infection premature baby in the same period were selected as control group.The levels of PCT,Alb,and IL-6 were compared,and the sensitivity and specificity of PCT,Alb,and IL-6 in the diagnosis of infections in preterm infants were evaluated. Results The levels of PCT and IL-6 in the infection group were (5.27±1.24) ng/L and (224.27±56.54) ng/L,which were significantly higher than non-infection group (0.66±0.29) ng/L and (85.31±12.13) ng/L in the control group (P<0.05);Alb level in the infection group was (24.97±6.27) g/L,which was significantly lower than (28.31±5.31) g/L in the control group (P<0.05).After the treatment,the levels of PCT and IL-6 in the infection group were significantly reduced to (0.54±0.34) ng/L and (82.47±13.84) ng/L (P<0.05);but Alb level was significantly increased to (29.45±5.83) g/L (P<0.05).The sensitivity and specificity of PCT+Alb+IL-6 in diagnosis of infections in preterm infants were significantly higher than that of single index (P<0.05). Conclusion PCT,Alb,and IL-6 could be used as clinical diagnostic indicators on infections in preterm infants,and the effect of three indicators combined were the best.Also three indicators could be used as the effective indicators to efficacy evaluation.