替吉奥胶囊治疗老年胃癌患者对血清sICAM-1、Survivin及肿瘤标志物水平的影响

目的 探究替吉奥胶囊治疗老年胃癌患者对患者血清中细胞凋亡抑制蛋白存活素(Survivin)、可溶性细胞间粘附因子-1(sICAM-1)及肿瘤标志物水平的影响。 方法 选择温州医科大学附属第三医院2013年5月-2015年11月治疗的62例老年胃癌患者,以随机数表法分组。对照组31例采用奥沙利铂+5-氟尿嘧啶(5-Fu)+亚叶酸钙方案治疗,观察组31例采用替吉奥+奥沙利铂方案治疗,均治疗3个疗程。统计对比2组临床疗效及毒副反应发生情况,检测对比2组治疗前后血管粘附因子(sVCAM-1)、sICAM-1、Survivin水平及肿瘤标志物变化情况。 结果 化疗前2组sICAM-1、sVCAM-1及Survivin水平比较差异无统计学意义(P>0.05);化疗后观察组sICAM-1、sVCAM-1及Survivin水平均低于对照组(P<0.05);化疗3个疗程后,观察组CEA、CA125及CA19-9水平低于对照组(P<0.05);2组治疗效果对比,差异无统计学意义(P>0.05);观察组胃肠道反应、白细胞减少总发生率低于对照组(P<0.05)。 结论 老年胃癌患者采用替吉奥胶囊联合奥沙利铂化疗效果显著,可有效降低sVCAM-1、sICAM-1、Survivin水平,降低肿瘤标志物水平,且安全性较高。 

Effect of S-1 capsule in the treatment of elderly patients with gastric cancer on serum sICAM-1,Survivin and tumor markers

Objective To explore the effect of S-1 capsule in the treatment of senile gastric cancer patients on apoptosis in serum inhibition protein (survivin) and soluble intercellular adhesion molecule-1(sICAM-1) and the influence of tumor markers. Methods Sixty-two elderly patients with gastric cancer were randomly into two groups in our hospital from May,2013 to November,2015.The control group (31 cases) was treated with oxaliplatin and 5-fluorouracil (5-Fu) and leucovorin regimen,the observation group (31 cases) were treated with S-1 and oxaliplatin treatment,they were treated for 3 courses.The clinical efficacy and adverse reactions were compared between the two groups.The vascular adhesion factor (sVCAM-1),sICAM-1,Survivin levels and tumor markers were compared before and after treatment in the two groups. Results There was no significant difference in the levels of sICAM-1,sVCAM-1 and Survivin between the two groups before chemotherapy (P>0.05);The levels of sICAM-1,sVCAM-1 and survivin in the observation group were lower than those in the control group (P<0.05);After 3 courses of chemotherapy,the levels of CEA,CA125 and CA19-9 in the observation group were lower than those in the control group (P<0.05);There was no significant difference between the two groups (P>0.05);The incidence of gastrointestinal reaction and reduction of WBC in the observation group was lower than that in the control group (P<0.05). Conclusion Elderly patients with gastric cancer using chemotherapy S-1 combined with oxaliplatin is effective and can effectively reduce the sVCAM-1,sICAM-1,survivin,reduce the levels of tumor markers,and has high safety.