雷公藤多苷联合替米沙坦对糖尿病肾病患者肾功能和血流变的影响

目的 探讨雷公藤多苷联合替米沙坦对糖尿病肾病患者肾功能和血流变的影响。 方法 以随机数字法将2014年6月—2016年1月温州医科大学附属黄岩医院收治的216例糖尿病肾病患者随机分为2组,每组108例。对照组给予替米沙坦,观察组在对照组的基础上加用雷公藤多苷。治疗前后,检测患者肾功能指标尿β2微球蛋白(β2-MG)、24 h尿微量白蛋白排泄率(UAER)、24 h尿蛋白定量(UP)、肾小球滤过率(GFR)]、血液生化指标血白细胞(WBC)、血清肌酐(Scr)、尿素氮(Bun)、糖化血红蛋白(Hb A1c)]、血液流变血浆黏度(PV)、纤维蛋白原(PF)、全血高切黏度(HBV)、全血低切黏度(LBV)];并统计2组的治疗效果。 结果 治疗后,2组β2-MG、UAER、UP、GFR水平均明显降低(P<0.05),且观察组β2-MG、UAER、UP、GFR水平改善情况优于对照组(P<0.05)。治疗后,2组WBC、Scr、Bun、Hb A1c水平均明显改善(P<0.05),且观察组WBC、Scr、Bun、Hb A1c水平的改善显著优于对照组(P<0.05)。治疗后,2组PV、PF、HBV、LBV水平均明显改善(P<0.05),且观察组PV、PF、HBV、LBV水平的改善显著优于对照组(P<0.05)。治疗后,观察组治疗总有效率为90.7%,显著高于对照组的79.6%(P<0.05)。 结论 雷公藤多苷联合替米沙坦可有效改善糖尿病肾病患者肾功能和血液微循环,治疗效果满意。 

Effect of tripterygium wilfordii polyglycoside combined telmisartan on renal function and hemorheology in patients with diabetic nephropathy

Objective To investigate the effect of tripterygium wilfordii polyglycosides combined telmisartan on renal function and hemorheology in patients with diabetic nephropathy. Methods Two hundred and sixteen cases of diabetic nephropathy were randomly divided into two groups, with 108 cases in each group. The patients in the control group received telmisartan, while the patients in the observation group received additional tripterygium wilfordii polyglycosides. Before and after the treatment, the renal function indicators (Urine β2-MG, UAER, UP and GFR), blood biochemical indicators (WBC, Scr, Bun, Hb A1c), hemorheology (PV, PF, HBV, LBV) of both groups were detected. And the total effective rate of two groups were accounted. Results After the treatment, β2-MG, UAER, UP and GFR levels of both groups were significantly improved (P < 0. 05), and the β2-MG, UAER, UP and GFR improvements of the observation group were significantly better than those of the control group (P < 0. 05). After the treatment, WBC, Scr, Bun and Hb A1 c levels of both groups were significantly improved (P < 0. 05), and the WBC, Scr, Bun and Hb A1 c improvements of the observation group were significantly better than those of the control group (P < 0. 05). After the treatment, PV, PF, HBV and LBV levels of both groups were significantly improved (P < 0. 05), and the PV, PF, HBV and LBV improvements of the observation group were significantly better than those of the control group (P < 0. 05). The total effective rate of the observation group was 90. 7%, which was significantly higher than that of control group (79. 6%, P < 0. 05). Conclusion Tripterygium wilfordii polyglycoside combined with telmisartan could effectively improve the renal function and hemorheology of patients with diabetic nephropathy, with satisfactory effect.