结外NK/T细胞淋巴瘤鼻型34例临床分析

［摘要］目的　分析结外NK/T细胞淋巴瘤鼻型的临床特点及治疗方案，提高对该特殊类型淋巴瘤的认识．方法　对经病理证实的结外NK/T细胞淋巴瘤鼻型患者34例的临床资料进行回顾性的分析．结果 　31例患者中，EB病毒（EBV）感染阳性组26例，近期疗效结果显示阳性组疗效显著低于阴性组（38.46% vs 87.50%；P＜0.05）．随访截至2015年10月，34例患者中，死亡19例．其中17例死于疾病复发或进展，2例死于其他疾病．15例患者生存，（其中11例无病生存），中位生存时间为37个月．患者2 a生存率与临床分期、B症状、EBV感染等有关（P值分别为0.017/0.001、0.005、0.039）．结论　EB病毒感染与患者的治疗反应有关；患者的预后与临床分期、B症状、EBV感染等临床特征有关．

Clinical Characteristic of 34 Patients with Extranodal Nasal Type NK/T-Cell Lymphoma

［Abstract］Objective　Analysis of clinical features and treatment of nasal type NK/T cell lymphoma, to improve the understanding of this special type of lymphoma．Method　The clinical data of 34 patients with nasal type NK/T cell lymphoma confirmed by pathology were retrospectively analyzed．Result　In 31 cases，26 cases were EB virus（EBV）infection positive，recent Treatment Effectiveness in the positive group was significantly lower than the negative group（38.46% vs. 87.50%；P＜0.05）. Follow up showed until October 2015, 19 of 34 patients died. Among them, 17 cases died of disease relapse or progression, 2 cases died of other diseases. 15 patients survived (11 of them were disease-free) and the median overall survival time was 37 months. The 2 year overall survival was related to clinical stage, B symptoms, EBV infection（the P values were 0.017/0.001，0.005，and 0.039 respectively)．Conclusion　EBV infection is associated with patient's treatment response in NK/T-Cell Lymphoma; and the prognosis is associated with clinical features such as clinical stage, B symptom，and EBV infection.