| 晚期肾癌靶向治疗的作用机制 耐药机制与对策 |
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| 引用本文： | 柯鑫文, 胡志全. 晚期肾癌靶向治疗的作用机制 耐药机制与对策[J]. 中国肿瘤临床, 2015, 42(24): 1159-1162. DOI: 10.3969/j.issn.1000-8179.2015.24.210 |
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| 作者姓名： | 柯鑫文 胡志全 |
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| 作者单位： | 作者单位:华中科技大学同济医学院附属同济医院泌尿外科(武汉市430030) |
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| 摘 要： | 随着对肾癌发生、发展过程中分子调控机制研究的不断深入，以分子信号通路中的关键蛋白酶/ 蛋白作为靶点开发靶向药物，较好地改善了晚期肾癌患者的治疗现状。但是靶向药物在治疗过程中常出现耐药，从而导致治疗效果降低。本文将对肾癌靶向治疗的作用机制、耐药机制与对策作简要综述。
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| 关 键 词： | 晚期肾癌 靶向治疗 作用机制 耐药机制 对策 |
| 收稿时间： | 2015-11-02 |
| 修稿时间： | 2015-12-06 |
Mechanisms of action,resistance, and countermeasures of targeted therapy in advanced renal cell carcinoma |
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| Xinwen KE, Zhiquan HU. Mechanisms of action, resistance, and countermeasures of targeted therapy in advanced renal cell carcinoma[J]. CHINESE JOURNAL OF CLINICAL ONCOLOGY, 2015, 42(24): 1159-1162. DOI: 10.3969/j.issn.1000-8179.2015.24.210 |
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| Authors: | Xinwen KE Zhiquan HU |
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| Affiliation: | Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | With the increasingly deepening research on the molecular regulatory mechanisms during the development and progres-sion of advanced renal cell carcinoma, the targeted therapy directed on the key proteinase/protein in the molecular signaling pathways significantly improves the management outcomes. However, the occurring resistance during therapy with targeted agents leads to de -creasing effects. The mechanisms of action, resistance, and countermeasures of targeted therapy in advanced renal cell carcinoma are simply reviewed. |
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| Keywords: | advanced renal cell carcinoma targeted therapy action mechanism resistance mechanism countermeasures |
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