脓毒症后认知功能障碍的研究进展

脓毒症(sepsis)是机体对感染反应的失控引发危及生命的全身性疾病,特点是发病率高、病死率高、花费高。尽管有大量的研究证实了有益的治疗策略,但临床的结局并不是十分好,脓毒症的总体病死率并没有得到显著的改善。而脓毒症引起的脏器损伤,尤其是损伤脑部引发的认知功能障碍,在临床中日显突出。脓毒症引起的认知功能障碍,表现为记忆力、注意力、视觉空间能力等的下降和执行困难,使得患者的生活质量下降,社会医疗和患者看护的成本增加,给社会和家庭带来了极大的负担。因此,重视脓毒症引起的认知功能障碍的预防和治疗是有积极意义的。本文综述了脓毒症后认知功能损伤的相关研究,从流行病学、危害、发病机制和救治现状来讨论这一问题,以便能够为读者提供参考。 

Progress of cognitive dysfunction after sepsis

Sepsis is a systemic disease with life-threatening organ dysfunction due to a dysregulated host response to infection,and characterized by high morbidity,high mortality and high cost.Despite of the fact that large number of studies has confirmed the beneficial therapeutic strategy,clinical results are not very satisfactory,and the overall mortality rate of sepsis has not been significantly improved.And organ damage induced by sepsis,especially cognitive dysfunction caused by brain injury resulting from sepsis is increasingly prominent in the clinic.Cognitive dysfunction caused by sepsis is performed by decline and executive dysfunctions in memory,attention,visuospatial ability and etc,thus it makes the patient's quality of life declined,makes the medical and social care costs increased,which is becoming a great burden for families and society.Therefore,the emphasis on prevention and treatment to sepsis brain injury is of great significance.This paper reviews the research on cognitive dysfunction resulting from sepsis,epidemiology,hazards,pathogenesis and treatment of the status quo to discuss this issue in order to provide reference for readers.