门静脉与外周血液胰岛素和C肽浓度的差异性

［摘要］目的　探索胰岛素和C肽浓度的变化评估肝脏功能的可行性．方法　同步抽取82例临床肝癌患者门静脉和外周血液，检测其胰岛素和C肽浓度，统计学分析门静脉和外周血液中胰岛素和C肽差异．结果　分析显示胰岛素在门静脉和外周血液浓度均值分别为32.43 μU/mL和8.05 μU/mL，存在差异有统计学意义（P＜0.05），C肽在门静脉和外周血液浓度均值分别为1.38 μU/mL和1.19 μU/mL，差异无统计学意义（P＞0.05）．结论　肝脏作为胰岛素的靶器官对胰岛素的代谢作用很大，C肽不参与体内代谢，因此通过对比分析胰岛素和C肽的代谢率的变化来评估肝脏功能是可行的．

The Difference in the Concentration of Insulin and c-peptide in Portal Vein and Peripheral Blood

［Abstract］Objective　To analyze the concentration changes of insulin and c peptide of in portal vein and peripheral blood， and explore the feasibility of using insulin and c peptide concentration changes in assessment of liver function. Methods The portal vein and peripheral blood samples were extracted from 82 clinical liver cancer patients，and the insulin and c peptide concentration were detected. The differences in the insulin and c peptide concentration in portal vein and peripheral blood were statistically analyzed. Results The insulin concentration in the portal vein and peripheral blood values were 32.43 μ U/ml and 8.05 μ U/ml， respectively， there was a significant difference（P＜0.05）. The c-peptide concentration in the portal vein and peripheral blood values were 1.38 μU/mL and 1.19 μg U/mL， respectively， there was no significant differences（P＞0.05）. Conclusion Liver metabolizes insulin as the target organ of insulin， while c-peptide dose not be metabolized in vivo， so it is possible to assess liver function by comparative analysis of the metabolic rate of insulin and c-peptide changes.