清热活血法联合西乐葆治疗痛风性关节炎的临床疗效及对患者VAS积分的影响

目的 评价清热活血法联合西乐葆治疗痛风性关节炎临床疗效及其安全性。 方法 选取台州市中心医院就诊的104例痛风性关节炎患者作为研究对象,采用随机数字表法将其分为观察组和对照组,每组52例。对照组患者给予西乐葆治疗;观察组患者在对照组的基础上给予清热活血法治疗,2组治疗时间均为7 d。治疗后观察2组患者临床疗效;治疗后第1、3、5、7天分别采用VAS评分对2组患者痛风关节疼痛程度进行评价;治疗后,比较2组患者关节红肿消失时间及关节疼痛缓解时间;治疗前后分别检测患者白细胞、肿瘤坏死因子-α及C-反应蛋白水平;观察治疗期间不良反应发生情况。 结果 观察组患者治愈率、显效率及总有效率分别为26.9%、46.2%和96.2%,均明显高于对照组(P<0.05);治疗第5天及第7天,观察组患者VAS评分分别为(1.31±0.31)分和(0.41±0.13)分,均明显低于对照组(P<0.05);观察组患者关节疼痛缓解时间和关节红肿消失时间均明显短于对照组(P<0.05);治疗后观察组白细胞、肿瘤坏死因子-α及C-反应蛋白水平分别为(6.82±1.53)×109/L、(63.2±4.4)pg/ml和(12.9±1.6)mg/L,均明显低于对照组(P<0.05);治疗期间2组均未发生严重不良反应。 结论 清热活血法联合西乐葆治疗痛风性关节炎的临床疗效及安全性均较好,值得开展深入研究。 

Efficacy of TCM reducing fever and promoting blood circulation method combined with celecoxib on Gouty Arthritis and its influence on VAS score

Objective To evaluate the efficacy and safety of TCM reducing fever and promoting blood circulation method combined with celecoxib in the treatment of gouty arthritis. Methods Total of 104 patients with gouty arthritis in our hospital were selected and randomly divided into two groups with 52 cases in each group.The control group received celecoxib treatment,while the treatment group received additional TCM reducing fever and promoting blood circulation method.The course was 7 days in both groups.After the treatment,the curative effect,VAS score on d1,d3,d5 and d7,joint swelling and pain lasted time were observed,and the WBC count,levels of tumor necrosis factor-α and C reactive protein,and incidence of adverse reaction were compared. Results The cure rate,excellence rate and overall response rate were 26.9%,46.2% and 96.2%,respectively,which were significantly higher than those in the control group (P<0.05).The VAS score at d5 and d7 were 1.31±0.31 and 0.41±0.13 in the treatment group,respectively,which was significantly lower than those in the control group (P<0.05).WBC counts,the levels of tumor necrosis factor and C reactive protein were (6.82±1.53)×109/L,(63.2±4.4) pg/ml and (12.9±1.6) mg/L in the treatment group,respectively,which were obviously lower than those in the control group (P<0.05).There was no serious adverse action in both two groups. Conclusion TCM reducing fever and promoting blood circulation method combined with celecoxib in the treatment of gouty arthritis is effective and safe,which worth to be studied in clinic.