阿替普酶静脉溶栓对急性脑梗死患者神经功能、炎症及氧化应激反应的影响

目的 探讨阿替普酶静脉溶栓治疗急性脑梗死对患者神经功能、炎症及氧化应激反应的影响。 方法 回顾性分析台州市中西医结合医院2013年1月—2016年6月间收治的142例急性脑梗死患者病例。观察组79例,给予阿替普酶静脉溶栓治疗,对照组63例给予常规治疗。治疗后,比较2组神经功能[美国国立卫生研究院卒中量表(NIHSS)、改良的Rankin’s量表(mRS)]、炎症[超敏C-反应蛋白(hs-CRP)、白细胞介素1β(IL-1β)、肿瘤坏死因子(TNF-α)]、氧化应激反应[超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-px)]及疗效。 结果 治疗后,观察组和对照组NIHSS水平显著降低(P<0.05),且观察组NIHSS水平显著低于对照组(P<0.05)。治疗后,观察组mRS水平显著低于对照组(P<0.05)。治疗后,观察组和对照组hs-CRP、IL-1β、TNF-α水平显著降低(P<0.05),且观察组hs-CRP、IL-1β、TNF-α水平显著低于对照组(P<0.05)。治疗后,观察组和对照组SOD、GSH-px水平显著升高,MDA水平显著降低(P<0.05),且观察组SOD、GSH-px水平显著高于对照组,MDA水平显著高于对照组(P<0.05)。观察组治疗总有效率为81.0%,显著高于对照组的63.5%(P<0.05)。 结论 阿替普酶静脉溶栓可有效改善急性脑梗死患者神经功能、炎症及氧化应激反应,效果满意。 

Effects of intravenous thrombolysis with alteplase on neurological function,inflammation and oxidative stress in patients with acute cerebral infarction

Objective To investigate the effects of intravenous thrombolysis with alteplase on neurological function, inflammation and oxidative stress in patients with acute cerebral infarction. Methods A total of 142 cases of acute cerebral infarction patients in our hospital from January, 2013 to June, 2016 were retrospectively analyzed. The patients in the observation group (79 cases) were received intravenous alteplase therapy, while the patients in the control group (63 cases) received routine therapy. After the treatment, the neurological function[National Institute of Health Stroke Scale (NIHSS), Modified Rankin 's Scale (mRS)], inflammation[hypersensitive C-reactive protein (hs-CRP), interleukin-1β (IL-1β), tumor necrosis factor (TNF-α)], oxidative stress[superoxide dismutase (SOD), malonaldehyde (MDA), glutathione peroxidase (GSH-px)], and clinical effect of the two groups were compared. Results After the treatment, NIHSS levels of the observation group and control group were significantly reduced (P < 0. 05), and NIHSS level of the observation group was significantly lower than that of control group (P < 0. 05). After the treatment, mRS level of the observation group was significantly lower than that of the control group (P < 0. 05). After the treatment, hs-CRP, IL-1β and TNF-α levels of the observation group and control group were significantly reduced (P < 0. 05), and hs-CRP, IL-1β and TNF-α levels of the observation group were significantly lower than that of the control group (P < 0. 05). After the treatment, SOD and GSH-px levels of the observation group and control group were significantly increase (P < 0. 05), and MDA levels of the observation group and control group were significantly reduced (P < 0. 05); and SOD and GSH-px levels of the observation group were significantly higher than that of the control group (P < 0. 05), MDA level of the observation group was significantly lower than that of the control group (P < 0. 05). The total effective rate of the observation group was 81. 0%, significantly higher than that (63. 5%) of control group (P < 0. 05). Conclusion Intravenous Alteplase thrombolysis could improve the neurological function, inflammation and oxidative stress in patients with acute cerebral infarction.