腋窝淋巴结阴性浸润性乳腺癌分子分型的表达及预后分析 |
| |
引用本文: | 张晓辉,徐雅莉,孙强,潘博,周易冬,茅枫,关竞红,林燕. 腋窝淋巴结阴性浸润性乳腺癌分子分型的表达及预后分析[J]. 中国肿瘤临床, 2014, 41(12): 793-796. DOI: 10.3969/j.issn.1000-8179.20140283 |
| |
作者姓名: | 张晓辉 徐雅莉 孙强 潘博 周易冬 茅枫 关竞红 林燕 |
| |
作者单位: | 中国医学科学院北京协和医院乳腺外科(北京市 100032) |
| |
基金项目: | 科技部国家科技支撑计划课题项目2014BA108B03 |
| |
摘 要: | 目的 探讨腋窝淋巴结阴性浸润性乳腺癌不同分子分型的分布,临床病理特征以及和预后的关系。 方法 回顾性分析183例该类乳腺癌患者的临床病理资料,对管腔上皮(Luminal)型、基底样(Basal-1ike)型和HER-2过表达(over-expression)型乳腺癌患者在年龄、肿瘤大小、临床分期和无瘤生存率(disease-free survival,DFS)、总生存率(overall survival,OS)方面进行统计分析。 结果 不同分子亚型乳腺癌在年龄、肿瘤大小、临床分期方面无显著性差异。Luminal、Basal-like、HER-2过表达型的复发率分别为3.9%(4/102)、20.4%(10/49)、6.3%(2/32)(P=0.002);死亡率分别为2.0%(2/102)、6.1%(3/49)、3.1%(1/32)(P>0.05)。Ka-plan-Meier分析显示Basal-like型的DFS最低(P=0.002),Basal-like型的OS较低(P=0.39)。Cox多因素比例风险模型分析显示分子亚型对DFS存在显著影响(P=0.001)。 结论 在腋窝淋巴结阴性浸润性乳腺癌患者中,不同分子亚型在年龄、肿瘤大小及临床分期方面无显著性差异,Basal-like型预后最差,分子分型是其独立预后指标。
|
关 键 词: | 乳腺癌 分子分型 生存 预后 |
收稿时间: | 2014-02-19 |
Molecular subtype and its association with prognosis in axillary lymph node-negative invasive breast cancer patients |
| |
Affiliation: | Department of Breast Surgery, Chinese Academy of Medical Science and Peking Union Hospital, Beijing 100032, China |
| |
Abstract: | Objective To analyze the distribution, clinico-pathologic features, and survival status of different subtypes in axillary lymph node-negative invasive breast cancer patients. Methods In this study, data of 183 patients were included and retrospectively analyzed in terms of age distribution, clinico-pathologic features, disease-free survival (DFS), and overall survival based on different subtypes (luminal, basal-like, and HER-2 over-expression). Results No significant differences in age, tumor size, and TNM stage was observed among different subtypes. The relapse rates of luminal, basal-like, and HER-2 over-expression subtypes were 3.9% (4/102), 20.4% (10/49), and 6.3% (2/32), respectively (P=0.002). The death rates of luminal, basal-like, and HER-2 over-expression subtypes were 2.0% (2/102), 6.1% (3/49), and 3.1% (1/32), respectively (P>0.05). Kaplan-Meier analysis showed that the DFS of basal-like subtype was much lower compared with that of the luminal and HER-2 over-expression subtypes (P=0.002). Cox analysis showed that the subtype was an independent prognostic indicator (P=0.001). Conclusion In node-negative invasive breast cancer, no significant differences in age distribution, tumor size, and TNM stage was observed among different subtypes. The basal-like subtype has the worst prognosis. Therefore, subtype is an important independent prognostic indicator. |
| |
Keywords: | |
|
| 点击此处可从《中国肿瘤临床》浏览原始摘要信息 |
|
点击此处可从《中国肿瘤临床》下载免费的PDF全文 |
|