| 多中心网状组织细胞增生症 1例 |
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| 引用本文： | 王白鹤,惠云,苑春雨,程伟,邵雪宝,陈浩,徐秀莲,孙建方.多中心网状组织细胞增生症 1例[J].中国麻风皮肤病杂志,2018,34(9):550-552. |
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| 作者姓名： | 王白鹤 惠云 苑春雨 程伟 邵雪宝 陈浩 徐秀莲 孙建方 |
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| 作者单位： | 中国医学科学院北京协和医学院皮肤病研究所，南京，210042 |
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| 摘 要： | 患者,男，65岁。手部皮色丘疹结节伴关节痛3月余，组织病理示：真皮可见大量组织细胞和多核巨细胞，胞体大，胞浆丰富，部分胞浆红染，呈“毛玻璃”样。PAS染色阳性，免疫组化Vimentin（+），CD68（+），CD1a（-），S100（-）。诊断：多中心网状组织细胞增生症。经“强的松、甲氨蝶呤、雷公藤”联合口服治疗后皮疹和关节症状明显改善。
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Multicentric reticulohistiocytosis: a case report |
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| WANG Baihe,HUI Yun,YUAN Chunyu,CHENG Wei,SHAO Xuebao,CHEN Hao,XU Xiulian,SUN Jianfang.Multicentric reticulohistiocytosis: a case report[J].China Journal of Leprosy and Skin Diseases,2018,34(9):550-552. |
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| Authors: | WANG Baihe HUI Yun YUAN Chunyu CHENG Wei SHAO Xuebao CHEN Hao XU Xiulian SUN Jianfang |
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| Institution: | Department of pathology，Institute of Dermatology，Chinese Academy of Medical Sciences and Peking Union Medical College，Nanjing 210042，China |
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| Abstract: | A 65-year-old man presented with hands papulonodular and arthritis for over 3 months. Histopathology examination showed many histocytes and multi-nucleated giant cells with eosinophilic cytoplasm and a ground-glass cytoplasm in the dermis. PAS staining was positive. Immunohistochemistry showed Vimentin (+), CD68 (+), CD1a (-), S100 (-). The diagnosis of multicentric reticulohistiocytosis was made. The patient was treated with oral methylprednisolone, methotrexate and tripterygium wilfordii. The rash and joint symptoms improved significantly. |
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