153例老年类风湿关节炎患者血清抗CCP抗体临床意义分析

目的 分析153例老年类风湿关节炎患者血清抗CCP抗体水平,评价血清抗CCP抗体检测在老年类风湿关节炎中的应用价值,旨在为该病的临床诊断提供参考依据。 方法 筛选出台州市第一人民医院2014年6月-2018年6月期间收治的153例老年类风湿关节炎患者,设为研究组,另筛选出本科室同期收治的153例其他风湿病患者以及体检中心的153例常规体检者,分别设为对照组与健康组,3组均运用酶联免疫吸附试验法检测血清抗CCP抗体水平,对比其检测结果,评价血清抗CCP抗体检测类风湿关节炎的临床应用价值。 结果 研究组的血清抗CCP抗体水平与阳性检出率均明显高于对照组与健康组,差异均有统计学意义(均P<0.05)。血清抗CCP抗体检测诊断老年类风湿关节炎的准确度、敏感度、特异度、阳性预测值、阴性预测值依次为77.8%、65.3%、84.9%、71.2%、81.0%。抗CCP阳性组患者的关节肿胀数、关节压痛数、DAS28评分、骨侵袭性破坏率均高于抗CCP阴性组,对比差异均有统计学意义(均P<0.05)。 结论 老年类风湿关节炎患者的血清抗CCP抗体水平与阳性检出率均较其他风湿病患者以及健康体检者明显提高;临床诊断该病时将血清抗CCP抗体与其他实验室指标联合检测,可进一步提高诊断准确性。 

Clinical analysis of serum anti-CCP antibodies in 153 elderly patients with rheumatoid arthritis

Objective To analyze the level of serum anti-CCP antibody in 153 elderly patients with rheumatoid arthritis and evaluate the application value of anti-CCP antibody detection in elderly patients with rheumatoid arthritis, and to provide reference for clinical diagnosis of this disease. Methods Total 153 elderly patients with rheumatoid arthritis admitted to our department from June, 2014 to June, 2018 were selected as the study group. Total 153 patients with other rheumatoid arthritis and 153 patients with routine physical examination in the physical examination center were selected as the control group and the healthy group, respectively.The serum anti-CCP antibody level was detected by the test method, and the results were compared, to evaluate the clinical value of serum anti-CCP antibody in the detection of rheumatoid arthritis. Results The levels of serum anti-CCP antibodies in the study group were significantly higher than those in the control group and the healthy group (P<0.05). The accuracy,sensitivity,specificity,positive predictive value and negative predictive value of anti-CCP antibody were 77.8%, 65.3%, 84.9%, 71.2% and 81.0%, respectively.The number of joint swelling,joint tenderness,DAS28 score and invasive bone destruction rate in anti-CCP positive group are higher than those in anti-CCP negative group (P<0.05). Conclusion The serum anti-CCP antibody level and positive detection rate of elderly patients with rheumatoid arthritis are significantly higher than those of other rheumatoid patients and healthy people.