血浆D-二聚体与食管鳞癌临床病理学特征的相关性 |
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引用本文: | 徐杰,齐大亮,李绪斌,王瑞霞. 血浆D-二聚体与食管鳞癌临床病理学特征的相关性[J]. 中国肿瘤临床, 2014, 41(2): 105-107. DOI: 10.3969/j.issn.1000-8179.20131744 |
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作者姓名: | 徐杰 齐大亮 李绪斌 王瑞霞 |
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作者单位: | ①.天津医科大学肿瘤医院高级病房,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室(天津市 300060) |
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基金项目: | 国家青年自然科学基金项目81201138 |
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摘 要: | 目的 通过对食管鳞癌患者术前血浆D-二聚体水平和术后病理T、N分期的相关性做回顾性分析,探讨血浆D-二聚体水平与食管鳞癌恶性程度的关系。 方法 选取本院2009年10月至2010年6月间101例无血液系统异常的食管鳞癌患者,对其术前血浆D-二聚体水平,术后病理T、N分期,组织学分级、转移N个数、肿瘤位置、肿瘤长径,病理分期等做统计学分析,探讨血浆D-二聚体水平与肿瘤转移、侵袭的关系。 结果 术前血浆D-二聚体水平与病理组织学分级、肿瘤长径的相关性均无统计学意义(P>0.05);而与T、N、TNM分期成正相关(P < 0.05),并与阳性淋巴结枚数呈显著正相关(P < 0.01)。此外,胸下段食管鳞癌患者术前血浆D-二聚体水平高于胸中上段者。 结论 食管鳞癌患者D-二聚体水平与T、N、TNM分期、阳性淋巴结枚数成正相关,具有重要的临床意义。
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关 键 词: | 食管鳞癌 D-二聚体 病理 分期 相关性 |
收稿时间: | 2013-10-18 |
Correlation between plasma D-dimer levels and clinicopathologic characteristics of esophageal squamous cell carcinoma |
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Affiliation: | ①.The VIP Ward, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin 300060, China②.Neurology Ward, Tianjin Medical University Second Hospital, Tianjin 300211, China |
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Abstract: | Objective To determine the relationship among tumor malignancy, invasion, and plasma D-dimer (DD) levels via a retrospective analysis of the correlation between preoperative plasma DD levels and postoperative pathology parameters in esophageal cancer patients. Methods A total of 101 esophageal cancer patients without coagulation among preoperative plasma DD levels and postoperative pathology parameters in esophageal cancer patients who underwent radical operation between January 2009 to April 2010 were enrolled. The preoperative plasma DD levels, postoperative pathology T, N Grade, number of metastatic lymph nodes, tumor position, tumor length, and TNM stage were recorded. A statistic analysis of the above parameters was performed to reveal the correlation between plasma DD levels and tumor pathology features. Results Preoperative plasma DD level has no correlation with Grade and tumor length, but shows positive correlation with pathology T, N status, and TNM stage, and has strong positive correlation with numbers of metastatic nodes. In addition, lower-third thoracic esophageal cancer patients have higher DD level than middle-third thoracic cases. Conclusion Plasma DD level has a positive correlation with T stage, N stage, TNM stage, and number of positive lymph nodes. It also has important clinical significance. |
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