| 胰腺癌细胞信号传导机制的研究进展 |
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| 引用本文： | 孔大陆,李强.胰腺癌细胞信号传导机制的研究进展[J].中国肿瘤临床,2015,42(14):724-727. |
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| 作者姓名： | 孔大陆 李强 |
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| 作者单位： | 作者单位:天津医科大学肿瘤医院肝胆肿瘤科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室(天津市300060) |
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| 摘 要： | 胰腺恶性肿瘤预后差，5 年生存率不足5% 。如何改善胰腺恶性肿瘤的治疗效果是目前国内外医学研究关注的焦点。随着对胰腺癌发病相关分子机制的深入研究，目前已经证实基因突变，如癌基因KRAS2，抑癌基因Cdkn2a 、TP53等，是胰腺癌发生的重要标志。因此进一步了解胰腺癌发病的相关分子机制，研究新的治疗策略是十分重要的。本文就近年来国内、外针对胰腺癌细胞信号传导机制的研究做如下综述。
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| 关 键 词： | 胰腺癌 信号通路 传导 |
| 收稿时间： | 2015-06-02 |
| 修稿时间： | 2015-06-25 |
Advances in signaling pathways of pancreatic cancer |
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| Dalu KONG,Qiang LI.Advances in signaling pathways of pancreatic cancer[J].Chinese Journal of Clinical Oncology,2015,42(14):724-727. |
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| Authors: | Dalu KONG Qiang LI |
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| Institution: | Department of Hepatobiliary Carcinoma, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China |
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| Abstract: | Pancreatic cancer has a very poor prognosis, with a five-year survival less than 5%. Nowadays, to improve the treat-ment efficacy of pancreatic cancer has been a highlight for medical researchers worldwide. Increasing knowledge about the molecular pathogenesis of the disease has shown that genic mutations, such as oncogene Kras2, and anti-oncogenes Cdkn 2a, and TP 53, are hall -marks of pancreatic cancer. Therefore, it is vital to deeply understand the pathogenetic mechanism of pancreatic cancer and find new therapeutic strategies to cover it. In this review, we summarized the recent advances in the signaling pathways of pancreatic cancer. |
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| Keywords: | pancreatic cancer signaling pathways transduction |
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