| 诊断模型对ALT正常值上限2倍以下慢性HBV感染者治疗指征的判断价值 |
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| 引用本文： | 蒋素文,胡爱荣,颜华东,金珊珊,胡耀仁.诊断模型对ALT正常值上限2倍以下慢性HBV感染者治疗指征的判断价值[J].中华全科医学,2017,15(4):558-561. |
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| 作者姓名： | 蒋素文 胡爱荣 颜华东 金珊珊 胡耀仁 |
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| 作者单位： | 1. 宁波市第二医院肝病诊治中心, 浙江 宁波 315010; |
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| 基金项目： | 浙江省区域专病中心建设专科(感染科)项目(2014-98)宁波市医学科技计划项目(2016C04)浙江省医药卫生省部培育计划项目(2014PYA018)浙江省宁波市科技计划社发重大项目(2016-C51005) |
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| 摘 要： | 目的 对比分析诊断模型(LIF-5、APRI及FIB-4)对丙氨酸转移酶(ALT)<2×正常值上限(ULN)慢性乙型肝炎病毒(HBV)感染者治疗指征(≥ G2或 ≥ S2)的判断价值。 方法 收集1 135例接受肝脏穿刺活检术患者的临床资料,分为0.75时,特异度97.3%、阳性预测值87.1%。 结论 有较高比例的ALT<2×ULN慢性HBV感染者存在明显肝脏疾病进展,诊断模型LIF-5对治疗指征的判断有较好的价值,值得推广。
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| 关 键 词： | 乙型肝炎 慢性 LIF-5 APRI FIB-4 病理学 诊断试验评价 |
| 收稿时间： | 2016-05-17 |
Analysis on the judgment values of three non-invasive score systems (LIF-5,APRI and FIB-4) for treatment indication in chronic HBV infected patients with ALT less than two times of upper limits of normal |
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| Institution: | Liver Disease Center, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, China |
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| Abstract: | Objective To comparatively analyze the judgment values of three non-invasive score systems (LIF-5,APRI and FIB-4),which were based on common indicators,for treatment indication (≥ G2 or ≥ S2) in chronic HBV infected patients with ALT less than two times of upper limits of normal (ULN). Methods The data of liver pathology and clinical characteristics in 1 135 chronic HBV infected patients with ALT<2×ULN were analyzed retrospectively.Patients were divided into (0.75 for treatment indication,the specificity and positive predictive value (PPV) were 97.3% and 87.1%. Conclusion There are still structural damage with liver inflammation ≥ G2 or fibrosis ≥ S2 in 44.49 per cent chronic HBV infected patients with ALT<2×ULN.The non-invasive score system with LIF-5 could predict treatment indication (≥ G2 or ≥ S2) with high accuracy,and is worth promoting. |
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