131I治疗术后分化型甲状腺癌的疗效及其影响因素

目的 分析大剂量131I治疗术后分化型甲状腺癌(DTC)患者疗效及其影响因素.方法 对216例DTC患者术后接受131I治疗的临床资料进行回顾性分析.对每次服131I后第4天131I全身显像进行对比观察作为判断疗效的依据,根据患者病理类型、转移部位、服131I次数分别观察其总体疗效.结果 大剂量131I治疗术后DTC患者总有效率86.57%,对于颈部淋巴结转移的疗效明显优于纵膈转移、肺转移及骨转移,无明显不良反应,安全可靠.结论 术后联合大剂量131I治疗对于分化型甲状腺癌是一种有效而又安全的方法,癌灶转移部位对131I治疗的疗效有一定的影响.

Clinical Curative Effect of Differentiated Thyroid Carcinoma Treated by Using Large 131I and 1st Influencing Factors

Objective To retrospectively analyze the curative effect of 131I therapy for treating post-operative differentiated thyroid carcinoma( DTC) and the influencing factors. Methods Two hundred and sixteen post-operative DTC patients who had received 131I therapy were involved in this retrospective study. The efficacy was assessed by 131I whole body scan in four days after the therapy every time. Besides,the overall curative effect was observed according to patients' pathological type,location of metastasis and frequency of 131I therapy respectively.Results After high dose 131I treatment, the total effective rate in patients with was 86.57%. The curative effect on cervical lymph node metastasis of DTC was significantly better than that of lung metastasis and bone metastasis.Meanwhile, no obvious side effects were observed during the study.Conclusions Large dose of 131I therapy for DTC metastasis is safe and effective. The location of tumor metastasis may influence the curative effect.