34例子宫内膜癌合并结直肠癌双原发癌的临床特征及其与Lynch 综合征关系分析

目的：探讨子宫内膜癌合并结直肠癌双原发癌患者的临床表现、治疗方法及其预后，并分析与Lynch 综合征关系。方法：回顾性分析中国医学科学院肿瘤医院34例子宫内膜癌合并结直肠癌双原发癌患者的临床病理资料。结果：34例患者的中位发病年龄为51.5（39~ 76）岁，64.7%（22/ 34）有肿瘤家族史，子宫内膜样腺癌占79.4%（27/ 34）。 34例中33例双原发癌患者行手术治疗，19例子宫内膜癌、17例结直肠癌术后行放化疗。2 年生存率为84.3% ，5 年生存率为63.1% 。结论：子宫内膜癌合并结直肠癌双原发癌患者多具有肿瘤家族史、发病年龄早、预后与散发型结直肠癌相近，部分患者符合Lynch 综合征。

Double primary carcinoma of endometrial carcinoma and colorectal carcinoma: retrospective analysis of 34cases and discussion of its relationship with Lynch syndrome

Objective:To approach the clinicopathologic characteristics, treatment modalities, and prognosis of the patients with double primary carcinoma of endometrial carcinoma and colorectal carcinoma and analyze the relationship between this disease and Lynch syndrome. Methods:The clinicopathologic and follow-up data of 34cases with double primary carcinoma of endometrial carci -noma and colorectal carcinoma treated in Cancer Hospital of Chinese Academy of Medical Sciences were reviewed. Results:The medi -an age of the34patients was 51.5 years old (ranging from 39to 76). Twenty-two of the total cases (22/34, 64.7%) had tumor family his-tory. The pathologic results indicated that 79.4% (27/34) was endometrioid adenocarcinoma. In the 34cases, 33were treated by surgical procedure. Of the33cases undergoing surgery, 17patients with endometrial carcinoma and 19with colorectal carcinoma received fur-ther adjuvant treatment of chemotherapy、 and /or radiotherapy. The 2- and 5-year survival rates were84.3% and 63.1% in the34cases, respectively.Conclusion:The age of onset is earlier in the patients with double primary carcinoma than in those with sporadic colorec -tal carcinoma. Some cases have cancer family history, and their survival rates are similar to those of the patients with sporadic colorec -tum carcinoma. Diagnosis of some patients with double primary carcinoma may be in line with Lynch syndrome.