| 肺癌诊治和预后判断分子标志物miRNA |
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| 引用本文： | 吉丛,喻长远,陈志华.肺癌诊治和预后判断分子标志物miRNA[J].中国肿瘤临床,2014,41(20):1333-1336. |
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| 作者姓名： | 吉丛 喻长远 陈志华 |
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| 作者单位： | ①.北京化工大学生命科学与技术学院（北京市100029） |
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| 摘 要： | 肺癌是目前全世界发病率第一、死亡率最高的肿瘤。肺癌的早期诊断和有效治疗是提高患者生存率的关键。miRNA是一类内源性、高度保守的非编码小分子RNA，在肺癌的发生、发展中起着重要作用。近年来，肺癌诊断、治疗和预后判断分子标志物miRNA的研究进展迅速，本文就miRNA作为肺癌早期诊断、预后判断和疗效预测分子标志物的研究进展，以及目前存在的问题做一综述。
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| 关 键 词： | 肺癌 miRNA 诊断 预后 治疗 |
| 收稿时间： | 2014-05-05 |
Molecular marker miRNA for the diagnosis,treatment and prognosis of lung cancer |
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| Institution: | ①.College of Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China②.Department of Biochemistry and Molecular Biology, Institute of Clinical Medical Sciences, China–Japan Friendship Hospital, Beijing 100029, China |
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| Abstract: | Lung cancer has the highest morbidity and mortality rate among malignant tumors. Early diagnosis and effective treatment are the keys to improving the survival of lung cancer patients. A type of endogenous, highly conserved, non-coding small molecule RNA (i.e., miRNA) was found to play an important role in the occurrence and development of this disease. Research on this molecular marker miRNA for the diagnosis, treatment and prognosis of lung cancer has rapidly progressed. This paper reviews the research work on miRNA as a molecular marker in the early diagnosis, treatment efficacy, and prognosis of lung cancer and explores some questions related to this disease. |
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