术前NLR PLR 与乳腺癌预后的相关性

目的:研究外周血中中性粒细胞和淋巴细胞绝对值的比值（neutrophil to lymphocyte ratio ，NLR ）、血小板和淋巴细胞绝对值的比值（platelet to lymphocyteratio ratio ，PLR ）与乳腺癌预后的相关性。方法:收集2011年1 月至2014年12月延边大学附属医院316 例行乳腺癌根治术患者的临床病理资料，分析NLR 、PLR 与乳腺癌TNM 分期、雌激素受体、HER-2 及三阴性乳腺癌之间的关系。结果:NLR 与乳腺癌TNM 分期之间有相关性（P < 0.05）、与乳腺癌雌激素受体、HER-2 及三阴性乳腺癌之间无相关性（P > 0.05），PLR 与乳腺癌TNM 分期及雌激素受体、HER-2 及三阴性乳腺癌之间均无相关性（P > 0.05）。 结论:术前NLR 水平作为全身炎症反应的指标可有效预测乳腺癌的预后。 

Correlation of preoperative neutrophil to lymphocyte ratio and platelet to lymphocyte ratio with prognosis of breast cancer

Objective:To assess neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in peripheral blood of breast cancer patients and to investigate their correlation with patient prognosis. Methods: Clinical data of316 patients with breast cancer, who underwent radical mastectomy between December2014 and January 2011 in The Affiliated Hospital of Yanbian University were collected. Clinical and pathological data including NLR, PLR, TNM staging, ER, HER-2 and triple-negative breast cancer were analyzed. Results: There was a significant correlation (P<0.05 ) between NLR and TNM staging in breast cancer. There was no significant correlation among NLR and the values of estrogen receptor (ER), HER- 2 and triple negative breast cancer (P>0.05 ). Also, there was no significant correlation among PLR and TNM staging, and the values of ER, HER-2 and triple-negative breast cancer ( P>0.05). Conclusion:NLR level before treatment, as an indicator of systemic inflammation, can effectively predict the prognosis of breast cancer.