甘肃省20~80岁汉族男性吸烟和饮酒的交互作用对γ-谷氨酰转肽酶的影响

目的 探讨甘肃省20~80岁汉族男性吸烟和饮酒的交互作用对γ-谷氨酰转肽酶（gamma-glutamyltransferase，GGT）的影响。方法 采用横断面研究方法，应用多阶段分层整群抽样，于2016年对甘肃省20~80岁汉族男性进行问卷调查、体格检查及实验室检测。采用分层分析和一般线性模型分析吸烟和饮酒的交互作用对GGT的影响。结果 共调查甘肃省男性1 646人。城镇和农村地区的吸烟年龄标化率分别是50.6%、49.2%，城镇和农村地区的饮酒年龄标化率分别是80.3%、74.5%。吸烟和饮酒对GGT存在正向交互作用（P=0.042）。在不吸烟者中，饮酒对GGT没有影响；戒烟时，饮酒≥ 61 g/d者GGT比不饮酒者高29.2（5.2~53.1）U/L；吸烟1~支/d时，饮酒≥ 61 g/d者GGT比不饮酒者高29.9（3.3~56.6）U/L；吸烟11~支/d时，饮酒≥ 61 g/d者GGT比不饮酒者高25.9（1.6~50.2）U/L；吸烟≥ 21支/d时，饮酒≥ 61 g/d者GGT比不饮酒者高86.8（12.9~160.7）U/L。结论 吸烟和饮酒对GGT存在正向交互作用，应注重控烟和限酒干预措施的同时实施。

The interaction of smoking and alcohol consumption on GGT in Han men aged 20-80 years in Gansu Province

Objective To study the interaction of smoking and alcohol consumption on gamma-glutamyltransferase(GGT) in Han men aged 20-80 years in Gansu Province. Methods A cross-sectional study was conducted in 2016, the Han men aged 20-80 years resident in Gansu Province were selected by using multi-stage stratified cluster sampling method. Questionnaire survey, physical examination and laboratory testing were conducted. Stratified analysis and general linear model were used to analyze the interaction of smoking and alcohol consumption on GGT. Results For 1 646 male subjects in Gansu, the age-standardized prevalence rates of current smoking in urban and rural areas were 50.6% and 49.2% respectively. The age-standardized prevalence rates of current alcohol consumption in urban and rural areas were 80.3% and 74.5% respectively. There was interaction effect of smoking and alcohol consumption on GGT (P=0.042). In non-smokers, alcohol consumption had no effect on GGT. In former smokers, the group who drink ≥ 61 g/d had an increased GGT of 29.2(5.2-53.1) U/L compared with no alcohol consumption group. In current smokers who smoke 1-cigarettes per day, the group who drink ≥ 61 g/d had an increased GGT of 29.9(3.3-56.6) U/L compared with no alcohol consumption group. In current smokers who smoke 11-cigarettes per day, the group who drink ≥ 61 g/d had an increased GGT of 25.9(1.6-50.2) U/L compared with no alcohol consumption group. In current smokers who smoke ≥ 21 cigarettes per day, the group who drink ≥ 61 g/d had an increased GGT of 86.8(12.9-160.7) U/L compared with no alcohol consumption group. Conclusions There is interaction effect between smoking and alcohol consumption on GGT, and intervention measures such as tobacco control and alcohol limitation should be implemented at the same time.