个性化护理对氯氮平致便秘的干预研究

目的 探讨个性化护理对应用非典型抗精神病药物导致便秘的干预作用。 方法 选取杭州市第七人民医院2014年7月—2016年5月符合纳入标准的因服用氯氮平导致便秘患者86例,按随机数字表法分为对照组和研究组,分别为43例,对照组予以常规护理;研究组予以个性化护理,2组共干预3个月为一疗程,治疗期间评定Longo出口梗阻评分、Wexner便秘严重度评分、胃肠生活质量评分以及焦虑自评量表(SAS)、抑郁自评量表(SDS)、简明健康调查问卷(SF-36)等,同时对比2组间护理效果以及满意度状况。 结果 与治疗前比较,2组治疗后Longo出口梗阻评分、Wexner便秘严重度评分降低,胃肠生活质量评分升高,治疗后SAS、SDS评分降低,SF-36评分升高(P<0.05);与对照组比较,研究组治疗后Longo出口梗阻评分、Wexner便秘严重度评分较低,胃肠生活质量评分较高,治疗后SAS、SDS评分较低,SF-36评分较高(P<0.05);研究组有效率(90.70%)高于对照组(72.09%),P<0.05;研究组满意率(88.37%)高于对照组(65.12%),P<0.05;所有患者均进行随访,无病例脱落现象,治疗期间肝/肾、血/尿、离子检测均处于正常范围,2组患者无不良反应出现。 结论 个性化护理对氯氮平所致的便秘疗效确切,可以改善便秘症状,提高生存质量,值得推广。 

Effect of personalized nursing on constipation caused by clozapine

Objective To explore the application of individualized nursing on clozapine lead to amelioration of constipation. Methods In our hospital in July 2014-2016 year in May in accordance with the inclusion criteria for clozapine caused 86 cases of constipation patients were randomly divided into study group and control group were 43 cases, the control group was given routine nursing the study group;two groups of individual nursing intervention for 3 months for a course of treatment during the assessment of Longo outlet obstruction constipation severity score, Wexner score, gastrointestinal quality of life score and self rating Anxiety Scale (SAS), self rating Depression Scale (SDS), concise Health Questionnaire (SF-36).At the same time comparison between the two groups of nursing effect and satisfaction condition. Results Compared with before treatment, scores of the two groups after treatment Longo outlet obstruction, Wexner constipation severity score decreased, quality of life score increased after treatment of gastrointestinal SAS, SDS score decreased, SF-36 scores were significantly increased (P < 0.05);compared with the control group, the Longo scores of the study group after treatment of outlet obstruction, Wexner constipation severity score lower gastrointestinal quality of life score higher, after treatment SAS, SDS score lower, higher SF-36 score (P < 0.05);the effective rate of control group72.09% and the effective rate was 90.70% of the research data comparison, study group than in control group (P <0.05);the control group satisfaction rate was 65.12% and the satisfaction rate of study group 88.37% data comparison, study group than in control group (P < 0.05);all patients were followed up, no cases of falling, during the treatment of liver/kidney.Blood/urine ion detection were in the normal range, no adverse reactions occurred in two patients. Conclusion The curative effect of individualized nursing on constipation induced by clozapine is effective, can improve constipation symptoms, improve the quality of life, worthy of promotion.