亮氨酸干预对门诊超重/肥胖2型糖尿病患者体成分、血糖及血脂的影响

目的 探讨亮氨酸对超重/肥胖2型糖尿病患者体成分、血糖及血脂的影响，为糖尿病的饮食治疗提供科学依据。方法 未进行胰岛素治疗的超重/肥胖2型糖尿病患者34人随机分为亮氨酸干预组和对照组，干预组每天补充3 g亮氨酸，持续3个月，期间维持正常用药及日常生活，干预前后测定相关指标。结果 干预组和对照组各15人完成研究。除干预组补充的亮氨酸，两组能量和营养素摄取差异均无统计学意义（均有P>0.05）；在基线水平上两组的体成分、血糖及血脂差异均无统计学意义（均有P>0.05）。干预结束后，干预组及对照组体重分别下降0.91 kg和0.83 kg，机体蛋白质含量分别增加0.17 kg和0.30 kg；另外，干预组空腹血糖下降0.37 mmol/L、对照组上升0.12 mmol/L。与对照组比较，干预组体重、体脂、蛋白质和骨骼肌差异均无统计学意义（均有P>0.05），空腹血糖、糖化血红蛋白以及血脂与对照组的差异也均无统计学意义（均有P>0.05）。干预前后各指标亦无明显变化。结论 连续3个月每天补充3 g亮氨酸没有改变超重/肥胖2型糖尿病患者体成分、血糖及血脂水平。

Effects of leucine intervention on body compositions,blood glucose and blood lipids in patients with type 2 diabetes mellitus with overweight/obesity

Objective To investigate the effects of leucine on body compositions, blood glucose and blood lipids in overweight/obese adult with type 2 diabetes mellitus, so as to provide the evidence for diabetic dietary therapy. Methods Thirty-four patients without insulin therapy were randomly divided into leucine intervention group and control group. The participants in the intervention group received 3 g of leucine per day. The study was lasted 3 months and the participants maintained their therapy and life style. The relative parameters were determined before and after the study. Results Thirty participants (15 in the intervention group and 15 in the control group) completed the study. There was no significant difference in body compositions, blood glucose and lipids between two groups at baseline. After intervention, the body weight decreased by 0.91 kg and 0.83 kg, and body protein increased by 0.17 kg and 0.30 kg in intervention group and control group, respectively. On the other hand, the fasting blood glucose decreased by 0.37 mmol/L in the intervention group and increased by 0.12 mmol/L in the control group. However, there were no significant differences in body weight, fat mass, muscle mass between the control and intervention groups. In addition, the plasma levels of fasting blood glucose, glycosylated hemoglobin and blood lipids were similar between two groups. Little change of these parameters was observed before and after the study. Conclusion Leucine supplementation of 3 g/day for 3 months has no effects on body compositions, blood glucose and blood lipids in overweight/obese adult with type 2 diabetes mellitus.