家庭化护理对产后抑郁症患者抑郁状况、生活质量和血清雌二醇、孕酮、5-羟色胺水平的影响

目的 探讨家庭化护理对产后抑郁症患者抑郁状况、生活质量和血清雌二醇、孕酮及5-羟色胺水平的影响。 方法 选择2015年2月—2017年2月郑州市妇幼保健院收治的138例产后抑郁症患者按随机数字法分为2组，每组69例。对照组给予常规护理，观察组给予家庭化护理。比较2组抑郁情况(EPDS评分)、生活质量(GQOLI-74评分)、血清雌二醇、血清孕酮及血清5-羟色胺水平情况。 结果 2组护理前EPDS评分、GQOLI-74各指标评分差异无统计学意义(均P>0.05)。护理后EPDS评分均显著降低，差异有统计学意义(P<0.05)，且观察组EPDS明显低于对照组(P<0.05)；2组躯体功能维度、社会功能维度与心理功能维度均明显提升，差异有统计学意义(均P<0.05)，且观察组各指标显著高于对照组(均P<0.05)。2组护理前血清雌二醇、血清孕酮及血清5-羟色胺水平评分差异无统计学意义(均P>0.05)；护理后血清雌二醇水平均显著升高(P<0.05)，且观察组明显高于对照组(P<0.05)。2组护理后血清孕酮显著降低(P<0.05)，且观察组明显低于对照组(P<0.05)，2组护理后血清5-羟色胺水平均明显上升(P<0.05)，且观察组显著高于对照组(P<0.05)。 结论 家庭化护理能够提高产后抑郁症患者抑郁状况、生活质量，并有效改善患者的雌激素和神经递质水平。 

Effects of family nursing on depression,life quality,serum estradiol,progesterone and serotonin of postpartum depression patients

Objective To investigate the effects of family nursing on depression,life quality and serum estradiol,progesterone and serotonin of postpartum depression patients. Methods A total of 138 cases of postpartum depression patients were randomly divided into two groups,with 69 cases in each group.The control group was given routine care and the observation group was given family care.The depression(EPDS score),life quality(GQOLI-74 score),serum estradiol,serum progesterone and serum serotonin levels of two groups were compared. Results Before nursing,the EPDS and GQOLI-74 scores of two groups had no significant differences(P>0.05);after nursing,the EPDS score of two groups was significantly reduced(P<0.05),and the EPDS score of observation group was significantly lower than that of the control group(P<0.05).The body function dimension,social function dimension and psychological function dimension of two groups were significantly increased(P<0.05),and each indicator score of observation group was significantly higher than that of the control group(P<0.05).Before nursing,the estradiol,progesterone and serotonin levels of two groups had no significant difference(P>0.05);after nursing,the estradiol levels of two groups were significantly increased(P<0.05),and estradiol levels of observation group was significantly higher than that of the control group(P<0.05);after nursing,the progesterone levels of two groups were significantly reduced(P<0.05),and progesterone level of observation group was significantly lower than that control group(P<0.05);after nursing,the serotonin levels of two groups were significantly increased(P<0.05),and serotonin levels of observation group was significantly higher than that of the control group(P<0.05). Conclusion Family nursing could improve the depressive status and life quality of postpartum depression patients and improve the estrogen and neurotransmitter levels.