H型高血压患者24小时动态血压变异性与同型半胱氨酸的关系

目的 探讨H型高血压患者24小时动态血压变异性与同型半胱氨酸的关系。 方法 选择浙江医院2014年2月-2016年11月H型高血压(同型半胱氨酸 ≥ 10 μmol/L)患者90例作为H型高血压组,原发性高血压(同型半胱氨酸<10 μmol/L)患者90例作为对照组。24小时动态血压仪测定2组患者24小时动态血压,比较2组患者的血压变异性,采用酶循环法测定血同型半胱氨酸水平。 结果 H型高血压组同型半胱氨酸水平高于对照组(P<0.05),H型高血压组空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白、血肌酐、血红蛋白水平与对照组比较差异无统计学意义(均P>0.05)。H型高血压组24小时收缩压变异性、24小时舒张压变异性、白天收缩压变异性、白天舒张压变异性、夜间收缩压变异性、夜间舒张压变异性均高于对照组(均P<0.05)。H型高血压患者24小时收缩压变异性、24小时舒张压变异性、白天收缩压变异性、白天舒张压变异性、夜间收缩压变异性、夜间舒张压变异性与同型半胱氨酸均呈正相关(均P<0.05)。 结论 H型高血压患者24小时动态血压变异性增加,24小时动态血压变异性与同型半胱氨酸呈正相关。 

Relationship between 24-hour ambulatory blood pressure variability and homocysteine in patients with H-type hypertension

Objective To explore the relationship between 24-hour ambulatory blood pressure variability and homocysteine in patients with H-type hypertension. Methods Total 90 patients with primary H-type hypertension (homocysteine ≥ 10 μmol/L) were treated as H-type hypertension group, and 90 patients with primary simple hypertension (homocysteine<10 μmol/L) were treated as control group in Zhejiang Hospital from February, 2014 to November, 2016. Twenty-four hours ambulatory blood pressure monitoring was performed in both groups by using 24 h ambulatory blood pressure meter, and the blood pressure variability was compared between the two groups. Blood homocysteine levels were determined by enzyme cycling. Results The homocysteine level in H-type hypertensive group was higher than that in the control group (P<0.05). There were no significant difference in fasting blood glucose, triglyceride, total cholesterol, low density lipoprotein, high density lipoprotein, serum creatinine and hemoglobin level between the two groups (all P>0.05). The variability of 24 h systolic blood pressure, the variability of 24 h diastolic blood pressure, the variability of daytime systolic blood pressure, the variability of daytime diastolic blood pressure, the variability of nighttime systolic blood pressure and the variability of night diastolic blood pressure in the H-type hypertensive group were higher than those in the control group (all P<0.05). The variability of 24 h systolic blood pressure, the variability of 24 h diastolic blood pressure, the variability of daytime systolic blood pressure, the variability of daytime diastolic blood pressure, the variability of nighttime systolic blood pressure and the variability of night diastolic blood pressure were positively correlated with homocysteine in the H-type hypertensive patients (all P<0.05). Conclusion Twenty-four-hour dynamic blood pressure variability increases obviously in patients with H-type hypertension, 24 h dynamic blood pressure variability is positively correlated with homocysteine.