复方丹参滴丸联合奥美拉唑治疗糖尿病并消化性溃疡的疗效分析及对患者血液相关指标的影响

目的 探讨复方丹参滴丸联合奥美拉唑对糖尿病并消化性溃疡患者血液流变学、血清一氧化氮(nitric oxide,NO)与内皮素(endothelin,ET)的影响。 方法 采用随机数字表法将2015年1月-2017年6月温岭市第一人民医院收治的132例糖尿病并消化性溃疡患者分为2组,每组66例。对照组给予奥美拉唑治疗,观察组在对照组基础上加用复方丹参滴丸。治疗4周后,比较2组临床疗效和血液流变学(全血高切粘度、全血低切粘度、血浆比粘度)、血清NO与ET水平。进而分析复方丹参滴丸联合奥美拉唑对糖尿病并消化性溃疡的疗效及潜在机制。 结果 观察组总有效率(95.45%)显著高于对照组(83.33%),差异有统计学意义(P<0.05)。治疗前,2组血液流变学、血清NO、ET水平比较,差异无统计学意义(均P>0.05)。治疗后,2组全血高切粘度、全血低切粘度及血浆比粘度水平均显著降低(均P<0.05),且观察组水平明显低于对照组(P<0.05)。治疗后,2组血清NO水平均显著升高(P<0.05),且观察组NO水平高于对照组(P<0.05);2组血清ET水平均明显降低(P<0.05),且观察组ET水平低于对照组(P<0.05)。 结论 复方丹参滴丸联合奥美拉唑治疗糖尿病并消化性溃疡临床疗效显著,其作用机制可能与其可有效改善患者微循环、调节血清NO与ET失衡有关。 

Effects of compound Danshen dripping pills combined omeprazole on peptic ulcer with diabetes mellitus and its impact on the hemorheology

Objective To investigate the effects of Danshen Dripping Pill combined Omeprazole on hemorheology, Nitric oxide (NO) and Endothelin (ET) of patients with diabetes mellitus and peptic ulcer. Methods Total 132 cases of peptic ulcer with diabetes mellitus in our hospital between January, 2015 and June, 2017 were randomly divided into two groups, with 66 cases in each group. The control group was given omeprazole, and the observation group was added compound Danshen Dripping Pill. After 4 week's treatment, the clinical efficacy, hemorheologywhole blood high shear viscosity, low blood viscosity, plasma specific viscosity], serum NO and serum ET levels of the two groups were compared. The effects and potential mechanism of Danshen Dripping Pill combined Omeprazole on patients with diabetes mellitus and peptic ulcer were analyzed. Results The total effective rate of the observation group was 95.45%, which was significantly higher than that of the control group (83.33%), P<0.05. Before the treatment, there was no significantly difference in hemorheology, NO and ET between the two groups (P>0.05). After the treatment, the high shear viscosity, low blood viscosity and plasma specific viscosity of the two groups were significantly decreased (P<0.05), and high shear viscosity, low blood viscosity and plasma specific viscosity of the observation group were significantly lower than those of the control group (P<0.05). After the treatment, the serum NO levels of both groups were significantly increased (P<0.05), and NO level of the observation group was significantly higher than that of the control group (P<0.05). After the treatment, the serum ET levels of the two groups were significantly decreased (P<0.05), and ET level of the observation group was significantly lower than that of the control group (P<0.05). Conclusion Danshen Dropping Pill combined Omeprazole can effectively improve peptic ulcer with diabetes mellitus. The mechanism might be related to the improvement of microcirculation and regulation of serum NO and ET.