慢性阻塞性肺病急性加重患者淋巴细胞组成变化

目的 探讨慢性阻塞性肺病急性加重时外周血主要淋巴细胞组成变化.方法 2014年1月1日至2014年12月31日, 因COPD急性加重入住昆明市第一人民医院行免疫功能检测的患者, 共789人次, 年龄最大为96岁, 最小为45岁, 平均 (76.33±9.56) 岁;统计结果采用 (x±s) 表示, 数据组间分析采用单因素方差分析.结果 789人次检查标本显示CD3+T淋巴细胞亚群均值为60.07±13.11, 低于正常参考值.根据不同年龄分组统计表明, 60岁以上年龄组CD3+T淋巴细胞亚群均值低于正常值, 50~59岁年龄组与60~69岁, 70~79岁, 80~89岁之间CD3+T淋巴细胞值有显著差异 (P<0.05) , 其它淋巴细胞亚群值在慢性阻塞性肺病急性加重时波动未超出正常参考值.结论 高龄慢性阻塞性肺病急性加重患者免疫功能下降, 不同年龄组间CD3+淋巴细胞亚群具有显著性差异.

Changes in Composition of Lymphocytes in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Objective To study the changes in the composition of main lymphocytes in peripheral blood of patients with AECOPD (acute exacerbation of chronic obstructive pulmonary disease) . Me thods From January1 th, 2014 to 31 th December, total 789 admitted patients with AECOPD received immunologic function test. Their age ranged from 45 to 96 years old (76.33 ±9.56) . Mean ±SD was used in statistics and groups difference was analyzed by one way analysis of variance. Re s ults The data of 789 samples showed that CD3+ T lymphocyte subpopulation mean value was 60.07 ±13.11, which was lower than normal parameter. There was significant differences among different age groups (F3.410, P0.009) .According to statistics of different age groups, mean value of CD3+ T lymphocyte subpopulation was lower than normal parameter in patients with age ≥60y. The mean value changes of other lymphocyte subpopulation were in normal range. Conclus ions There is lower immunology function in patients with senile AECOPD, and the value of CD3+ T lymphocyte is significant difference among different age groups.