尿毒清颗粒合并氯沙坦治疗高血压合并高尿酸血症的临床研究

目的 探讨尿毒清颗粒合并氯沙坦治疗高血压合并高尿酸血症的临床疗效。 方法 选择2015年1月—2016年3月瑞安市人民医院收治的168例高血压合并高尿酸血症的患者,采用随机数字法分为观察组和对照组,每组84例。对照组采用氯沙坦治疗,观察组在氯沙坦基础上加用尿毒清颗粒。治疗前后,检测2组患者的血压和尿酸相关指标[收缩压(SBP)、舒张压(DBP)和血尿酸(UA)],内皮细胞功能[一氧化氮(NO)、血管性假性血友病因子(vWF)]、RAS活性相关指标[血浆卧位肾素、血管紧张素Ⅱ(AngⅡ)]、血脂相关指标[甘油三酯(TG)、胆固醇(TCG)、高密度脂蛋白(HDL-C)],并统计不良反应发生率和治疗效果。 结果 治疗后,2组SBP、DBP、血尿酸、vWF、卧位肾素、AngⅡ、TG、TCG均明显降低(P<0.05),且观察组各指标显著低于对照组(P<0.05);治疗后,2组NO水平均明显升高(P<0.05),且观察组NO水平明显高于对照组(P<0.05)。观察组总有效率为91.7%,显著高于对照组的79.8%(P<0.05)。 结论 尿毒清颗粒合并氯沙坦可抑制RAS系统过度激活,改善内皮细胞功能,有效降低患者血压和血尿酸含量,治疗效果满意。 

Clinical study of uremic clearance granule combined losartan in treatment of hypertension with hyperuricemia

Objective To investigate the clinical efficacy of uremic clearance granule combined with losartan in the treatment of hypertension with hyperuricemia. Methods Total 168 cases of hyperuricemia with hyperuricemia in our hospital between January, 2015 and March, 2016 were selected and divided into observation group and control group (n=84) by random number method.The patients in the control group were given losartan, while the patients in the observation group were added uremic clearance granule based on losartan.Before and after the treatment, blood and uric acid indicators[systolic blood pressure (SBP), diastolic blood pressure (DBP), and uric acid (UA)], endothelial cell function[nitric oxide (NO), Von Willebrand factor (vWF)], RAS activity indicators[plasma supine renin, Angiotensin Ⅱ (Ang Ⅱ)], blood lipids indicators[triglycerides (TG), cholesterol (TCG) and high density lipoprotein (HDL-1)]of two groups were tested, and the adverse reactions and clinical efficacy of the two groups were accounted. Results After the treatment, the levels of SBP, DBP, uric acid, vWF, adrenaline, Ang Ⅱ, TG and TCG HDL-C in both groups were significantly reduced (P <0.05), and each indexes of the observation group were significantly lower than those of the control group (P < 0.05).The NO levels of the two groups were significantly increased (P < 0.05), NO level of the observation group was significantly higher than that of control group (P < 0.05).The total effective rate of the observation group was 91.7%, which was significantly higher than that of control group (79.8%), P < 0.05. Conclusion Uremic clearance granule combined losartan could inhibit the over-activation of RAS system, improve the function of endothelial cells, effectively reduce the blood pressure and blood uric acid content, with satisfactory treatment.