心血管因素及血清半胱氨酸水平升高与脑梗死患者1年死亡风险的相关性研究

目的 探讨研究脑梗死患者1年死亡风险的心血管因素,分析脑梗死患者1年死亡风险与血清半胱氨酸(Hcy)的相关性。 方法 临床纳入185例宁波市鄞州人民医院2013年9月-2016年9月期间收治的脑梗死患者进行研究。患者出院后随访1年并收集所有患者资料,观察纳入对象的生存情况。对比死亡患者与生存患者一般资料情况,根据Logistic回归方程计算脑梗死患者1年死亡的危险因素,探讨血清半胱氨酸水平升高与患者1年死亡风险的关系。 结果 随访患者1年,发现185例患者中死亡21例,生存患者164例,生存率为88.65%。脑梗死生存和死亡患者在心脏形态、颈动脉斑块以及Hcy水平上均有差异,均P<0.05。采用Logistic回归方程进行计算,结果发现心脏形态、颈动脉斑块以及Hcy水平均是脑梗死患者1年死亡风险的危险因素(P<0.05),其风险比(OR)分别为0.126、0.142、0.151。 结论 心脏形态、颈动脉斑块以及Hcy水平是引起脑梗死患者死亡的危险因素,Hcy水平升高可增加脑梗死患者病死率。临床上实施心脏原发病、颈动脉斑块以及降Hcy治疗可有效提高脑梗死患者生存率,降低病死率,值得临床应用及推广。 

Correlation of cardiovascular factors and elevated serum cysteine level with one-year mortality risk in patients with cerebral infarction

Objective To study the cardiovascular factors of one-year mortality risk in patients with cerebral infarction and analyze the correlation between one-year mortality risk and serum cysteine (Hcy) level. Methods The clinical study was carried out in 185 patients with cerebral infarction admitted in our hospital between September, 2013 and September, 2016. The patients were followed up for one year to collect the data for observing the survival of the subjects. By comparing the general data of death patients and survival patients, we calculated the risk factors of one-year mortality of patients with cerebral infarction according to the Logistic regression equation, and discussed the relationship between the increase of serum cysteine level and the one-year mortality risk of patients with cerebral infarction. Results In one year follow-up, 21 of 185 patients died and 164 survived, with a survival rate of 88.65%. The different in cardiac morphology, carotid plaque and Hcy level were noted between survival patients and died patients, P<0.05. Logistic regression equation showed that the morphological structure of heart (OR:0.126), carotid plaque (OR:0.142) and Hcy level (OR:0.151) were the risk factors of one-year mortality risk in patients with cerebral infarction (P<0.05). Conclusion The risk factors of cerebral infarction within one year include the cardiac morphology, carotid plaque and Hcy levels; with the increase of Hcy levels, the death rate of cerebral infarction patients will increase obviously.