非小细胞肺癌免疫检查点阻断剂治疗进展* |
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引用本文: | 孟祥姣,邢力刚,于金明.非小细胞肺癌免疫检查点阻断剂治疗进展*[J].中国肿瘤临床,2015,42(18):887-890. |
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作者姓名: | 孟祥姣 邢力刚 于金明 |
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作者单位: | 作者单位:山东省肿瘤防治研究院放疗科(济南市250117) |
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摘 要: | 目前大部分肺癌患者就诊时已是晚期,不宜手术切除,主要采用放疗、化疗和靶向治疗等综合治疗,5 年生存率较低。免疫检查点阻断剂通过调整机体的免疫系统功能,打破肿瘤细胞免疫逃逸机制,使T 细胞活化并清除肿瘤细胞,成为一种有效的肿瘤治疗方式。目前免疫检查点阻断剂在非小细胞肺癌(non-small celll ung cancer ,NSCLC )临床试验中取得一定疗效,很多研究正在开展,这有可能改变NSCLC 的治疗模式。本文将阐述免疫检查点阻断剂在NSCLC 中的治疗作用及联合其他治疗的应用前景。
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关 键 词: | 非小细胞肺癌 免疫检查点阻断剂 治疗 |
收稿时间: | 2015-07-25 |
Advances in immunocheckpoint blockades in the treatment of non-small cell lung cancer |
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Institution: | Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan250117 , China |
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Abstract: | In China, most patients with non-small cell lung cancer (NSCLC) were diagnosed with advanced or metastatic disease on first admission. These patients were treated by chemotherapy, radiotherapy, or targeted therapy. However, the 5-year overall survival rate is still low. Immunocheckpoint blockades adjust the immune function, dispatch immune escape, enhance T cell activation, and kill tumor cells. Immunocheckpoint blockade becomes one of the important methods of anti- tumor treatments. This approach may also change the model of NSCLC treatment because of its promising anti-tumor activity. This review summarizes the clinical trials on immu -nocheckpoint blockades in NSCLC and the possibility of combining this technique with other treatments. |
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