| 肠道菌群与结直肠癌关系研究进展* |
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| 引用本文： | 詹宏杰,梁寒.肠道菌群与结直肠癌关系研究进展*[J].中国肿瘤临床,2015,42(13):675-679. |
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| 作者姓名： | 詹宏杰 梁寒 |
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| 作者单位： | 作者单位:天津医科大学肿瘤医院胃部肿瘤科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室(天津市300060) |
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| 摘 要： | 人体肠道菌群代谢成分通过与受体结合、刺激炎症因子分泌，与其他变化一起，引起炎症反应，最终导致结直肠癌（colorectal cancer ，CRC ）的发生。而肠道内的益生菌则通过屏障作用、抑制DNA 损伤等机制保护肠道黏膜，抵御CRC 的发生，并可被用于预防及辅助治疗CRC 。胃肠道手术可以影响肠道菌群的代谢，影响微生态平衡。本文将针对肠道菌群与结直肠癌关系的最近进展进行综述。
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| 关 键 词： | 肠道菌群 结直肠癌 益生菌 手术 |
| 收稿时间： | 2015-02-06 |
Research progress on the relationship between intestinal microflora and colorectal cancer |
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| Institution: | Department of Gastric Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin300060, China |
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| Abstract: | Metabolic components of human intestinal flora bind to their corresponding receptors and stimulate inflammatory cy-tokine secretion. Other changes become evident and cause inflammation, as a result, colorectal cancer (CRC) occurs. Probiotics protect intestinal mucosa and prevent CRC by functioning as an intestinal barrier and inhibiting DNA damage. Probiotics can also be used not only to prevent CRC but also to induce adjuvant treatment of CRC. Gastrointestinal tract surgery can affect gut microbiota metabolism and microecological balance. This review focuses on current research progress on the relationship between intestinal microflora and CRC. |
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