磷酸奥司他韦颗粒治疗流感样患儿疗效观察

目的 观察磷酸奥司他韦颗粒治疗流感样患儿的临床疗效。 方法 收集2017年9-11月蚌埠医学院第一附属医院儿科门急诊就诊的流感样患儿共87例,随机分成2组。治疗组44例,给予热毒宁静脉滴注及磷酸奥司他韦颗粒口服,连续给药5 d;对照组43例,仅给予热毒宁静脉滴注,同样连续给药5 d。观察2组患儿病情变化、不良反应及预后情况,了解磷酸奥司他韦颗粒疗效及安全性。 结果 治疗前2组患儿在一般情况、病情严重程度及化验血常规等方面差异无统计学意义;治疗后治疗组发热消退时间为(27.52±6.32) h,对照组发热消退时间为(36.13±8.51) h,治疗组发热消退时间明显低于对照组,差异具有统计学意义(P<0.05);治疗组总有效率93.2%,对照组为76.1%,治疗组总有效率明显高于对照组,差异具有统计学意义(P<0.05);治疗组4例行病原学检测,2例甲型流感阳性,对照组2例行病原学检测,结果均为甲型流感阳性,因样本太小,未进行统计学检验;不良反应轻微,均为胃肠道反应,治疗组有恶心呕吐3例,改换服用方式后缓解。 结论 磷酸奥司他韦颗粒治疗流感样患儿,发热消退时间明显缩短,完成药物疗程者更利于退热。且不良反应小,应用安全,值得临床推广。 

Curative effect of oseltamivir in the treatment of flu-like children

Objective To observe the clinical curative effect of oseltamivir in the treatment of flu-like children. Methods A total of 87 cases of flu-like children accepted by the first affiliated hospital of Bengbu Medical College between September, 2017 and November, 2017 are randomly divided into two groups. They are oseltamivir group and control group with 44 and 43 cases respectively. The oseltamivir group are treated with reduning injection and oseltamivir granules, and the control group reduning only. Both groups are treated for 5 consecutive days, to be observed on the development, side effect, and prognosis, so as to find out the curative effect and safety of oseltamivir. Results There is no significant difference between the normal condition, severity and blood routine of both groups before treatment. The time of fever's coming down of oseltamivir group is (27.52±6.32) h. It is shorter than that of control group with the time of (36.13±8.51) h. The difference is statistically significant (P<0.05). The total effective rates of the two groups are 93.2% and 76.1% respectively. The total effective rate of oseltamivir group is higher than that of control group. The difference is statistically significant as well(P<0.05). There are 4 cases from oseltamivir group and 2 cases from control group which are tested for H1N1. Two of oseltamivir group and that two from control group are positive. However, the sample is too small to do statistical test. There are 3 cases of nausea and vomiting in oseltamivir group,and getting better after changing the way of taking medicine. Conclusion Comparing the oseltamivir group and control group of cases accepted by the first affiliated hospital of Bengbu Medical College, the fever's coming down time of oseltamivir group is significantly shorter than that of control group. Oseltamivir is mild in side effect and safe to use. Therefore, it is worthy to popularize.