安徽省阜阳市HIV/HCV共感染者抗病毒治疗服药依从性及影响因素分析

目的 探讨安徽省人类免疫缺陷病毒（human immunodeficiency virus，HIV）/丙型肝炎病毒（hepatitis C virus，HCV）共感染者抗病毒治疗服药依从性现状及其影响因素，为制定综合管理策略提供理论依据。方法 采用横断面研究方法，对安徽省阜阳市接受抗病毒治疗1年以上的HIV/HCV共感染者进行问卷调查，收集患者的一般信息和服药情况，采用多因素Logistic回归分析对其服药依从性的影响因素进行分析。结果 256例HIV/HCV共感染者在过去1个月内抗病毒治疗的服药不依从率为34.0%，结婚年限较长（OR=3.049，95%CI:1.435~6.481，P=0.004）、抗病毒治疗时间较长（OR=1.803，95%CI:1.251~2.599，P=0.002）和饮酒者（OR=2.512，95%CI:1.152~5.478，P=0.021）抗病毒治疗依从性较差，而女性（OR=0.180，95%CI:0.089~0.366，P<0.001）和设置服药提醒者（OR=0.315，95%CI:0.159~0.626，P=0.001）的抗病毒治疗依从性较好。结论 降低社会公众的艾滋病歧视和提高HIV/HCV共感染者抗病毒治疗的信心，是改善抗病毒治疗服药依从性的关键。

Study on influencial factors of adherence to anti-retroviral treatment among people who co-infected with HIV/HCV in Fuyang City,Anhui Province

Objective To investigate the adherence to anti-retroviral treatment and related factors among human immunodeficiency virus (HIV) and hepatitis C virus (HCV) co-infectors. Methods In this cross-sectional study, 256 HIV and HCV co-infectors were recruited by convenience sampling method, and information about demography, taking medicine and therapy were collected and analyzed. Results A total of 256 HIV/HCV co-infectors were investigated, 34.0% of them missed dose in the last month. Multiple Logistic regression analysis showed that HIV/HCV co-infectors with long marriage (OR=3.049, 95% CI:1.435-6.481, P=0.004), longer time of treatment with antiretroviral therapy (ART) (OR=1.803, 95% CI:1.251-2.599, P=0.002), frequent alcohol consumption (OR=2.512, 95% CI:1.152-5.478, P=0.021) were risk factors of missed dose, while female (OR=0.180, 95% CI:0.089-0.366, P<0.001) and co-infectors who take a reminder method (OR=0.315, 95% CI:0.159-0.626, P=0.001) were protective factors for missed dose. Conclusions The ART adherence rate of HIV/HCV co-infectors was lower in Anhui Province, comprehensive intervention measures should be taken to promote the ART adherence.