长期生存直肠癌患者生存质量的临床影响因素分析

  目的  探讨Ⅱ/Ⅲ期直肠癌长期无瘤生存患者生存质量的临床影响因素。  方法  对107例Ⅱ/Ⅲ期直肠癌无瘤生存5年以上的患者进行生存质量问卷调查, 分析其临床影响因素。  结果  保肛者的躯体、角色、情绪、社会功能较造口者好, 性功能影响较造口者小, 但大便情况较造口者差(P < 0.05);治疗手段增多患者的社会功能和总体健康状况下降, 疲倦和失眠越明显(P < 0.05); Logistic回归分析显示治疗方式是影响Ⅱ/Ⅲ期长期生存直肠癌患者生存质量的独立因素, 呈负相关, 即治疗手段增多, 生存质量有所下降。  结论  治疗方式是Ⅱ/Ⅲ期无瘤生存直肠癌患者生存质量的独立预后因素, 手术方式是影响患者生存质量的主要因素。改进医疗技术, 合理的放化综合治疗, 有助于提高患者的长期生存质量。 

Analysis of influecing factors of quality of life in rectal cancer patients with long-term survival

  Objective  To investigate the influencing factors of quality of life (QOL) in rectal cancer patients with long-term survival (LTS).  Methods  A total of 107 patients with stage Ⅱ and Ⅲ rectal cancers were enrolled in this study.Questionnaires were used to determine the clinical factors affecting the QOL of rectal cancer patients with LTS.  Results  Physical, emotional, social, and sexual functions were better in patients without colostomy than in those who underwent surgery.However, bowel function was worse in patients who did not undergo surgery (P < 0.05).A decrease in social function and QOL was observed in patients who underwent more treatments, and fatigue and insomnia symptoms were more obvious (P < 0.05).Logistic regression analysis indicated that treatment was an independent predictor of QOL and negatively correlated with QOL.  Conclusion  Treatment is an independent predictor of QOL in patients with stageⅡand Ⅲ rectal cancers, and is negatively correlated with QOL.Surgery is a major factor that affects patient QOL. Improvement of medical technology and reasonable chemoradiotherapy should ameliorate the QOL of patients with LTS.