| 食品中典型有机污染物和重金属的毒性通路研究进展 |
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| 引用本文： | 陆伟,郑唯韡,郑玉新,何更生,屈卫东.食品中典型有机污染物和重金属的毒性通路研究进展[J].中华疾病控制杂志,2018,22(10):983-986. |
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| 作者姓名： | 陆伟 郑唯韡 郑玉新 何更生 屈卫东 |
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| 作者单位： | 1. 复旦大学公共卫生学院环境卫生学教研室 公共卫生安全教育部重点实验室, 上海 200032; |
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| 基金项目： | 国家重点基础研究发展计划"食品安全关键技术研发"重点专项项目（2017YFC1600200、2017YFC1600500） |
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| 摘 要： | 食品污染是影响食品安全和人群健康的重要风险因素。《21世纪毒性测试愿景与战略》提出未来的毒性测试应充分考虑人群暴露可能，基于体外人源性细胞系、高通量筛选和毒性通路的毒性测试战略，试图解决传统毒性测试成本高昂、耗时费力、种属差异方面的挑战。本综述围绕我国食品污染问题突出的典型重金属和有机污染物，分析归纳了有关毒性通路研究现况，并展望未来的研究方向。
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| 关 键 词： | 毒性通路 食品污染物 暴露 计算机毒理学 |
| 收稿时间： | 2018-08-21 |
Research progressions in toxicity pathways of typical organic pollutants and heavy metals in food |
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| Institution: | 1. Key Laboratory of Public Health Safety, Ministry of Education, Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China;2. Department of Labor Health and Environmental Health, School of Public Health, Qingdao University, Qingdao 266021, China |
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| Abstract: | Food contamination is vital risk factor influencing food safety and population health. "Toxicity Testing in 21st Century:A Vision and a Strategy" addressed toxicity in the future should consider population and exposure data and set the strategy for toxicity test based on in vitro assay, human cell lines, high throughput screenings, and toxicity pathway, which are attempt to solve the challenges encountered by traditional toxicity testing in high-cost, time-consuming, resource-intensive, and species differences. This review focuses on the typical heavy metals and organic pollutants, the prominent issues of food contamination in China, which analyzes and summarizes the current status on toxic pathways research, and gives perspective future research in the field. |
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