发作期抑郁症患者不同情绪面孔刺激下的P300研究

目的 探讨高兴、中性、悲伤三种情绪面孔刺激对于发作期抑郁症患者执行持续注意任务时的P300影响。 方法 对33例18～58岁抑郁症患者(病例组，其中应激组17例，无应激组16例)和18名20～58岁健康对照者(对照组)进行视觉脑诱发电位检测，要求被试在高兴、中性、悲伤三种情绪面孔刺激随机呈现后执行注意与选择任务，分别观察病例组和对照组在不同情绪面孔刺激诱发下P300潜伏期和波幅，采取两因素重复测量方差分析分别统计各组之间P300潜伏期和波幅差异；利用Pearson积差相关分析分别进行病例组HAMA、HAMD总评分与P300波幅、潜伏期相关性分析。 结果 应激组、无应激组分别在高兴、中性面孔刺激后P300波幅均低于对照组，差异有统计学意义(P<0.05)，应激组、无应激组分别在悲伤面孔刺激后P300波幅都低于对照组，但仅无应激组与对照组差异有统计学意义(P<0.05)；应激组、无应激组在高兴、中性、悲伤情绪面孔刺激后P300潜伏期均大于对照组，且差异有统计学意义(P<0.05)。 结论 发作期抑郁症患者在执行持续注意任务时对于高兴、中性面孔情绪的辨别能力有所减弱，情绪偏向影响发作期抑郁患者持续注意认知。 

Different emotional facial stimuli in patients with major depressive disorder by event-related potential P300

Objective To explore the effects of three kinds of emotional facial stimuli(happy,neutral and sad) on P300 in patients with depressive episode during continuous attention task. Methods Thirty-three cases of 18-58 years old patients with depression(case group,the stress group 17 cases,16 cases of non stress group) and 18 aged 20-58 years old healthy subjects(control group) were detected in brain visual evoked potentials participants were asked to perform tasks in the attention and selection after happy,sad and neutral emotional faces of stimuli were randomly presented.The latency and amplitude of P300 were observed in the case group and the control group in different emotional faces evoked by stimulation.P300 latency and amplitude differences were assessed by the two way ANOVA statistics between the groups; The correlation of HAMA,HAMD total scores and P300 latency and amplitude were assessed respectively by person correlation analysis in the case group. Results The stress group and non stress group were in happy and neutral faces after the stimulation of the amplitude of P300 is lower than that of the control group,the difference was statistically significant(P<0.05),stress group and non stress groups were in sad faces after the stimulation of the amplitude of P300 is lower than that of the control group,but only the non stress group and control group of the difference was statistically significant(P<0.05);stress group and non stress group in the happy,neutral and sad faces after the stimuli of P300 latency were higher than the control group,and there is statistically significant(P<0.05). Conclusion The patients with major depressive disorder in the implementation of sustained attention task for the happy,neutral facial emotion recognition ability have weakened.Emotional bias has influence on depression in patients with sustained attention to cognition.