Localized muscular mucormycosis in a child with acute leukemia |
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Authors: | Kang CM; Kim HS; Song KS; Lee HJ; Kwon KY |
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Institution: | Department of Pediatrics, Keimyung University, School of Medicine, Taegu, Korea. |
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Abstract: | Mucormycosis is a rare fungal infection of childhood, occurring mainly in
patients with chronic illnesses such as diabetes and malignancies. The
fungus seldom grows in culture and confirmation of the diagnosis depends on
histologic examination of infected tissues. To date, the reported natural
history of the disease has been rapid progression and a fatal outcome.
Therefore, the importance of early diagnosis by tissue biopsy and early
treatment with surgical debridement and systemic antifungal therapy cannot
be overemphasized. The pulmonary system is the most common site for
mucormycosis in patients with leukemia. We report what we believe to be the
first successfully treated case of isolated muscular mucormycosis occurring
in a child with biphenotypic acute leukemia. The diagnosis was made
promptly by tissue examination at the time of surgical debridement. The
patient was also given systemic amphotericin-B therapy.
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