正电子发射体层显像在头颈部肿大淋巴结定性中的临床价值

目的　探讨正电子发射体层显像 (PET)检查对于头颈部肿大淋巴结定性的应用价值。方法　对 1999年 3月～ 2 0 0 1年 10月 2 7例伴头颈部淋巴结肿大的患者行全身18氟 脱氧葡萄糖(FDG) PET检查 ,测取相应淋巴结的最大标准摄取值 (SUVmax)、平均标准摄取值 (SUVmean)和正常颈部组织的SUV(SUVneck)。所有恶性淋巴结全部得到病理确诊。结果　 2 1例恶性肿瘤淋巴结肿大患者中 ,2 6个肿大淋巴结对FDG的摄取能力明显高于相应的正常颈部组织 (SUVmax ,SUVmean和SUVneck分别为 4 6 2± 2 31,3 4 5± 2 74和 0 5 5± 0 0 8,P <0 0 0 1)。其余 6例 9个良性肿大淋巴结未见显影。PET对头颈部淋巴结肿大定性诊断准确率高于颈部超声与CT、MR检查 (P <0 0 0 1)。结论　对于头颈部淋巴结肿大的患者 ,PET检查是一种有效的定性诊断途径

The usefulness of FDG-PET in patients with cervical lymphadenopathy

OBJECTIVE: To assess the usefulness of 2-(fluorine-18) fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in patients with cervical lymphadenopathy. METHODS: From March 1999 to October 2001, 27 patients with cervical lymphadenopathy were imaged with FDG-PET. Maximum and mean standard uptake value (SUVmax and SUVmean) of lymphadenopathy and SUV of normal cervical tissue (SUVneck) were measured. All 21 patients with malignant lymphadenopathy got pathologically confirmed. RESULTS: All 26 malignant lymph nodes in 21 patients could be detected by FDG-PET. FDG uptake of these nodes was higher than that of cervical tissue (SUVmax, SUVmean and SUVneck were 4.62 +/- 2.31, 3.45 +/- 2.74 and 0.55 +/- 0.08, respectively P < 0.001). Other 9 benign lymph nodes in 6 patients couldn't be detected by FDG-PET. The accuracy of PET in 21 patients with malignant lymphadenopathy, was higher than those of routine examinations such as ultrasonography plus CT or MR (P < 0.001). CONCLUSIONS: FDG-PET allows effective diagnosis of patients with cervical lymphadenopathy and can contribute substantially to patient care.