| 顺铂前体脂质体的制备及包封率测定 |
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| 引用本文： | 马晶,邓树海. 顺铂前体脂质体的制备及包封率测定[J]. 中国医院药学杂志, 2006, 26(4): 416-418 |
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| 作者姓名： | 马晶 邓树海 |
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| 作者单位： | 1. 济南盛泽医药科技开发有限公司,山东,济南,250100
2. 山东大学药物制剂研究所,山东,济南,250012 |
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| 摘 要： | 目的:对顺铂前体脂质体制备工艺及包封率测定方法进行初步研究。方法:选用山梨醇为水溶性载体,采用前体脂质体法与超声分散混合法制备顺铂前体脂质体;高效液相色谱法测得包封率。结果:制得的顺铂前体脂质体为球形双层脂质体,包封率为71.8%。结论:本法制备的顺铂前体脂质体,在水化前便于贮存,重新混悬时易于分散、工艺简单、可规模化生产、包封率高;高效液相色谱法测定顺铂的含量,方法简便、准确。
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| 关 键 词： | 顺铂 前体脂质体 包封率 高效液相色谱法 |
| 文章编号： | 1001-5213(2006)04-0416-03 |
| 收稿时间： | 2005-02-05 |
| 修稿时间： | 2005-02-05 |
Preparation of pro-liposomes of cisplatin and determination of encapsulation percentage |
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| MA Jing,DENG Shu-hai. Preparation of pro-liposomes of cisplatin and determination of encapsulation percentage[J]. Chinese Journal of Hospital Pharmacy, 2006, 26(4): 416-418 |
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| Authors: | MA Jing DENG Shu-hai |
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| Affiliation: | 1. Shengze Pharmaceutical Research and Develpoment Company, LTd. , Shandong Jinan 250100,China,2. Pharmaceutical preparation institute of Shandong University,Shandong Jinan 250012,China |
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| Abstract: | OBJECTIVE To Study the preparation of pro-liposomes of cisplatin and determination method of encapsulation percentage.METHODS Cisplatin liposomes were prepared by the technology of pro-liposome and sonication,using sorbitol as water-solubility carrier, and encapsulation percentage was determined by HPLC.RESULTS The cisplatin liposomes were double-layer sphericity, the average encapsulation percentage was 71.8%.CONCLUSION The pro-liposomes can be easily reserved before hydrated, and could be well dispersed when suspended in water.The technology is simple and convenient for industrial production, and a relatively high encapsulation percentage can be obtained;The determination method of HPLC is simple and convenient for precise. |
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| Keywords: | cisplatin pro-liposome encapsulation percentage HPLC |
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