急性河豚毒素中毒患者神经电生理的研究

目的 研究急性河豚毒素（TTX）中毒患者神经电生理的改变。方法 检测58例TTX中毒患者的肌电图，运动神经传导速度（MCV），感觉神经传导速度（SCV），F波，H反射和体感诱发电位（SEP）。结果 22例TTX中毒患者（37．9％）肌电图以多相不规则波为主，MCV，SCV均有减慢，以SCV减慢最为显著，MCV远端动作电位潜伏期明显延长，神经传导速度（NCV）的异常率比纤颤，正尖波检出率高，F反应，H反射异常提示部分TTX中毒累及神经根；SEP的异常率达56．9％。结论 TTX中毒可伴有中枢神经的损害。神经电生理检测可用来动态观察其神经系统损害程序，病程，范围，亦是TTX中毒时早期检查的重要手段之一。

Electrophysiological studies in patients with acute tetrodotoxin poisoning

Objective To evaluate the electrophysiological change in patients with acute tetrodotoxin(TTX) poisoning.Methods The electromyogram, motor nerve conduction velocity(MCV), sensory nerve conduction velocity(SCV),F wave,H reflex and somatosensory evoked potentials(SEP) were randomly detected in 58 patients with acute TTX poisoning.Results 22 patients with TTX(37.9%) detected by the electromyogram showed mainly polyphase irregular waves;MCV and SCV were weakened; SCV was even more remarkable,the latency of distant MCV action potentials was prolonged obviously, the abnormality rate of nerve conduction velocity was much higher than that of fibrillation,the detectable rats of positive wave was high,the low abnormality rate of F wave and H reflex suggested that the ill TTX poisoning involved the nerve roots;the abnormality rate of SEP was 56.9%.Conclusion TTX poisoning can company with the damage of central nerves, the measure of electroneurophysiology can be used to observe the extent,course and range of nerve system damage in patients with acute TTX poisoning, and it is one of the early detection means of this disease.