Expression of circulating smooth muscle actin （ACTG2） in the patients with unstable angina

Background Acute coronary syndrome(ACS) is a leading cause of mortality and morbidity worldwide,which comprises unstable angina(UA) and acute myocardial infarction(AMI), and the investigation of biological markers to assess those most at risk of recurrent cardiovascular events is necessary. Methods Sixty-six healthy control people and 67 cases of UA patients were enrolled in Guangdong general hospital. Enzyme linked immunosorbent assay(ELISA) was used to detect the level of plasma ACTG2. The receiver operating characteristic curve(ROC) was used to analyze the prediction value of ACTG2 for UA. According to the average level of plasma ACTG2 in UA patients, UA patients were divided into the low ACTG2 group( average level) and the high ACTG2 group(≥ average level), and the differences in clinical characteristics between the two groups were investigated. Results The ELISA result showed that the level of plasma ACTG2 was67.823 ± 58.479 pg / m L in healthy people, while the plasma ACTG2 was 94.514 ± 65.453 pg / m L in UA patients, with a significant difference(P 0.05). ROC analysis result showed that the Area under curve(AUC)for the prediction of UA was 0.653(95% CI 0.559-0.747), with a high statistical significance, indicating that circulating ACTG2 may possess high prediction value for UA. In addition, among the 67 UA patients, 39 were allocated to the low ACTG2 group and 28 to the high ACTG2 group. Comparison of the baseline characteristics between the two groups showed that patients in the high ACTG2 group were older than those in the low ACTG2 group. In addition, levels of Lipoprotein(a)(Lpa), Total bilirubin(TBIL) and Pro-Brain Natriuretic Peptide(Pro BNP) in the high ACTG2 group were also higher than those in the low ACTG2 group.Conclusions Circulating ACTG2 could significantly increase in UA patients, which may be used as a biomarker for the prediction of UA.