血尿酸水平与帕金森病患病率及其认知功能改变、病情分级相关性探讨

目的探讨帕金森病(Parkinson's disease,PD)患者的血尿酸与帕金森并认知功能障碍及病情分级的相关性。方法选择87例30⁸5岁的门诊健康体检者作为对照组,66例3085岁的门诊健康体检者作为对照组,66例30⁸5岁帕金森病患者纳入研究,为PD组,通过Moca量表筛查认知功能障碍患者,把PD组分为认知功能障碍组及认知功能正常组两个亚组。测定空腹血尿酸,对比分析PD患病率、认知功能及其病情分级与血尿酸水平是否存在相关性。结果 PD组血尿酸水平明显较对照组低。PD认知功能障碍组血尿酸水平低于PD认知功能正常组。血尿酸水平与PD严重程度无统计学意义。结论帕金森患者血尿酸水平减低很可能为帕金森病及帕金森病认知功能障碍的危险因素之一。但不可以用来评定疾病严重程度。

CORRELATION OF SERUM URIC ACID LEVELS WITH THE PARKINSON＇S DISEASE AND ITS COGNITIVE IMPAIRMENT

Objective To discuss the relationship between serum uric acid levels and clinical stages, cognitive dysfunction in Parkinson＇s disease（PD）. Method Eighty - seven cues of healthy person were collected from the Health Examination Centers as control group. Sixty - six patients of PD were enrolled. The patients of PD were randomized into two groups according to the Moca score, including the cognition impairment group and the normal cognition group. The levels of serum uric acid were examined and compared. Result The serum uric acid levels in PD group were significantly lower than those in normal control group. The serum uric acid levels in the cognition impairment group were lower than those in normal cognition group. There was no correlation between differ- ent Hoehn - Yahr stage period of PD group. Conclusion Low level of the serum uric acid might to be a risk factor for PD and its cog- nitive impairment, but cannot be used to assess the severity of disease.