中枢神经系统白血病脑脊液中白细胞介素2受体、铁蛋白和纤维结合蛋白的变化及其临床意义

目的探讨中枢神经系统白血病脑脊液中可溶性白细胞介素2受体、铁蛋白和纤维结合蛋白的变化及其临床意义。方法采用酶联免疫吸附法检测中枢神经系统白血病组(CNSL组),无中枢神经系统白血病组(无CNSL组)脑脊液中可溶性白细胞介素2受体、铁蛋白和纤维结合蛋白的变化。结果 CNSL组脑脊液中可溶性白细胞介素2受体、铁蛋白和纤维结合蛋白均高于无CNSL组和对照组,有显著性差异(p<0.05)。结论脑脊液中可溶性白细胞介素2受体、铁蛋白和纤维结合蛋白在中枢神经系统白血病的诊断中有重要意义,提示其联合检测对早期诊断中枢神经系统白血病有意义。

CHANGES AND CLINICAL INDICATIONS OF INTERLEUKIN- 2 RECEPTOR,FERRITIN AND FIBRINECTIN IN THE CEREBROSPINAL FLUID OF CENTRAL NERVOUSE SYSTEM LEUKEMIA

Objective To investigate the changes and clinical indications of interleukin-2 receptor,ferritin and fibrinectin in the cerebrospinal fluid of central nervous system leukemia. Methods ELISA was used to detect the changes ofsoluble interleukin- 2 receptor,ferritin and fibrinectin in the cerebrospinal fluid of central nervous system leukemia group（CNSL） and non-CNSL group. Results The concentrations of soluble interleukin-2 receptor,ferritin and fibronectin incerebrospinal fluid of the CNSL group were significantly higher than those in non- CNSL group and the control group（ p〈 0. 05）. Conclusion The soluble interleukin 2 receptor,ferritin and fibronectin in cerebrospinal fluid are indicative of central nervous system leukemia. The result suggests that combined detection is important in early diagnosis of central nervous system leukemia.