影响胃食管反流病抑酸疗效的高危因素分析

目的研究影响胃食管反流病抑酸疗效的因素。方法本研究以2011年5月²013年12月我院确诊的420例胃食管反流病患者为研究对象,采用问卷调查和临床检查的方式收集患者的信息,通过单因素分析和logistic回归分析影响胃食管反流病抑酸疗效的因素。结果年龄每增大1岁或BMI每升高1 kg/m2,胃食管反流病患者的抑酸疗明显降低,其OR值及95CI%分别为1.07(1.032013年12月我院确诊的420例胃食管反流病患者为研究对象,采用问卷调查和临床检查的方式收集患者的信息,通过单因素分析和logistic回归分析影响胃食管反流病抑酸疗效的因素。结果年龄每增大1岁或BMI每升高1 kg/m2,胃食管反流病患者的抑酸疗明显降低,其OR值及95CI%分别为1.07(1.03¹.11);1.12(1.071.11);1.12(1.07¹.17)。饮酒者、并发抑郁者、并发焦虑者以及并发肠易激综合征者的抑酸疗效比不饮酒者、未并发抑郁者、未并发焦虑者以及未并发肠易激综合征者明显降低。结论年龄、BMI、饮酒、并发焦虑抑郁以及肠易激综合征是影响胃食管反流病抑酸疗效的高危因素。

THE RISK FACTORS ANALYSIS OF RESPONSE TO CID SUPPRESSION THERAPY IN GAS- TROESOPHAGEAL REFLUX DISEASE PATIENTS

Objective To investigate the risk factors of response to acid suppression in Gastroesophageal reflux disease （GERD） patients. Method A total 420 GRED patients from May 2011 to December 2013 in our hospital were recruited in the stud- y. Quality - of - life questionnaire and clinical examination were uesd to collect the information of patients. Univariate analysis and multiple linear regression analysis was used to investigate the risk factors of response to acid suppression in GERD patients. Result Increases in age by 1 year or in BMI by 1 kg/m2, the responses to acid suppression in GERD patients significantly decreased （ 1.07 （ 1.03 - 1.11 ） ; 1.12 （ 1.07 - 1.17 ）, respectivly ）. Drinkers, concurrent anxiety, complicated with depression or irritable bowel syndrome were at lower response to acid suppression in GERD patients compared to those patients with non - drinkers, unconsolidated anxiety, unconsolidated depression and unconsolidated irritable bowel syndrome. Conclusion Age, BMI, alcohol consumption, con- current anxiety and depression and irritable bowel syndrome are risk factors affecting the efficacy the acid suppression of GRED patients.