| 去甲长春花碱联合顺铂治疗食管癌52例 |
| |
| 引用本文： | 吴云,严晓春. 去甲长春花碱联合顺铂治疗食管癌52例[J]. 中华肿瘤防治杂志, 2003, 10(12): 1292-1293 |
| |
| 作者姓名： | 吴云 严晓春 |
| |
| 作者单位： | 淮安市楚州医院肿瘤科,江苏,淮安,223200 |
| |
| 摘 要： | 目的 :观察去甲长春花碱 (NVB)联合顺铂 (DDP)治疗晚期食管癌的疗效和毒副反应。方法 :随机将 5 2例晚期食管癌患者分为两组。NVB组 :NVB 2 5mg m2 ,静脉推注 ,d1、d5;DDP 30mg m2 ,静脉滴入 ,d2 ～d4。对照组 :醛氢叶酸 (CF) 0 1,静脉滴入 ,d1～d5;5 FU 0 5mg m2 ,静脉滴入 ,d1～d5;DDP 30mg m2 ,静脉滴入 ,d2 ～d4。 2个方案均每 4周重复 ,每例化疗 2个周期。结果 :NVB组总有效率 5 3 3% ,对照组 4 2 3% ,P >0 0 5 ;主要毒副反应为骨髓抑制 ,NVB组白细胞减少发生率为 88 5 % ,对照组为6 5 4 % ,P >0 0 5 ,NVB组成本疗效比大于对照组。结论 :NP方案适合用于复治患者
|
| 关 键 词： | 食管肿瘤/药物疗法 长春碱/投药和剂量 顺铂/投药和剂量 抗肿瘤药 多剂联用 |
| 文章编号： | 1009-4571(2003)12-1292-02 |
| 修稿时间： | 2003-05-29 |
Clinical Observation of Vinorebine Combined with Cisplatin in Treatment of Advanced Esophageal Carcinoma |
| |
| WU Yun,YAN Xiao-chun. Clinical Observation of Vinorebine Combined with Cisplatin in Treatment of Advanced Esophageal Carcinoma[J]. Chinese Journal of Cancer Prevention and Treatment, 2003, 10(12): 1292-1293 |
| |
| Authors: | WU Yun YAN Xiao-chun |
| |
| Affiliation: | WU Yun,YAN Xiao-chun.Department of Medical Oncology,Chuzhou Hospital of Huaian City,Huaian 223200,China |
| |
| Abstract: | Objective To evaluate the effect and side effect of Vinorebine combined with cisplatin in the treatment of advanced esophageal carcinoma.Methods Fifty-two cases of advomced esophageal carcinoma were randomized into two groups,vinorebine group(NP) and control group(LFP).Results The response rate was 53.8%(14/26) in the vinorebine group and 42.3%(11/26) in the control group,P>0.05.Main toxicities were neutropenia with occurrence rate of 88.5% in the vinorelbine group and 65.4% in the control group,P<0.05.Conclusion Vinorebine plus cisplatine could be considered as salvage treatment regimen for refractory carcinoma of esophagus. |
| |
| Keywords: | esophageal neoplasms/drug therapy vinblastine/administration & dosage cisplatin/administration & dosage antineoplastic agents combined |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
