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Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats |
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| Authors: | Jian Xu Huai C Yan Bo Yang Lu S Tong Yu X Zou Ying Tian |
| Affiliation: | (1) Shanghai Key Laboratory of Children's Environmental Health, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute for Pediatric Research, No. 1665 Kong Jiang Road, Shanghai, 200092, PR China;(2) Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, No. 1678 Dong Fang Road, Shanghai, 200127, PR China;(3) Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Brisbane, Queensland, 4059, Australia |
| Abstract: | BackgroundA complete explanation of the mechanisms by which Pb2+ exerts toxic effects on developmental central nervous system remains unknown. Glutamate is critical to the developing brain through various subtypes of ionotropic or metabotropic glutamate receptors (mGluRs). Ionotropic N-methyl-D-aspartate receptors have been considered as a principal target in lead-induced neurotoxicity. The relationship between mGluR3/mGluR7 and synaptic plasticity had been verified by many recent studies. The present study aimed to examine the role of mGluR3/mGluR7 in lead-induced neurotoxicity. |
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