药物性肝炎120例临床分析

目的探讨药物性肝炎的病因、临床特点,以提高对药物性肝炎的诊治水平。方法根据患者的原发病、服药史、临床表现、肝功能、血清标志物及停药后的治疗效果综合判断。结果引起肝损害的药物多见于抗结核药物(25.0%),抗肿瘤药物(23.3%),中草药,特别是治疗皮肤病和风湿骨关节病、肾炎等疾病的中草药(15.0%),抗感染药物(11.6%)和抗真菌药物(6.7%)等。大多数药物性肝炎出现于服药后1~2月。结论临床应重视药物性肝病的预防、诊断和治疗。

Clinical study on drug-induced hepatitis

Objective To determine the causes and the clinical features of drug-induced hepatitis so as to enhance the levels of diagnosis and treatment.Methods Such indexes as underlying diseases,medication history,time of onset,clinical manifestations,laboratory tests,response to drug medication,etc.,were studied by means of review.Results Antituberculous drugs stood out as the first drug related to drug-induced hepatitis(25.0%).The second cause was antineoplastics(23.3%).Others included traditional Chinese medicine(15.0%) and antibiotics(11.6%).Most cases' incubation period was 1-2 months.Conclusion Many drugs may cause drug-induced hepatitis.Clinicians should draw attention to the prevention,diagnosis and therapy of drug-induced hepatitis.