电针对非酒精性脂肪肝大鼠血脂及脂质过氧化反应的影响

目的：研究电针对非酒精性脂肪肝（Non—alcoholic fatty liver disease，NAFLD）大鼠血脂及脂质过氧化反应的影响。方法：用高脂饲料诱导大鼠脂肪肝模型，同时给予电针治疗，观察肝组织病理形态的变化。测定血清甘油三酯（TG）、总胆回醇（TC）、高密度脂蛋白胆回醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）；肝内丙二醛（MDA）、超氧化物歧化酶（SOD）、甘油三酯（TG）、总胆固醇（TC）以及谷胱甘肽（GSH）含量的变化。结果：与脂肪肝模型组比较，电针组的肝组织脂肪变性和炎性损伤得以改善。血清TC、TG、LDL—C，肝内MDA、TG、TC显著降低，血清HDL—C，肝内SOD、GSH活性升高。结论：电针通过降低血脂，抑制氧化过程，减轻脂质过氧化反应，使肝组织的脂肪变性和炎性损伤得以改善。

Effect of Electric Acupuncture on Nonalcoholic Fatty Liver Rats and Lipid Peroxidation in Rats

Objective ： To investigate the infuluence of electroacupuncture on non - alcoholic fatty liver rats serum lipids and oxidation＇ s impact. Methods.with high fat diet -induced fatty liver model, while providing electroacupuncture treatment, observed liver tissue pathology morphological changes. Determination of serum triglyceride （ TG ）, total cholesterol （ TC ）, high density lipoprotein cholesterol（ HDL - C）, low -density lipoprotein cholesterol （LDL - C）and the Intrahepatic malondialdehyde （ MDA）, Superoxide dismutase （ SOD）, Triglycerides （ TG）, Total cholesterol （ TC ） and glutathione （GSH） content changes. Result ： Comparde with fatty liver model group, Electroacupuncture group ＇ s liver organization fat denaturation and the inflammation damage can improve, Serum TC,TG, LDL - C, the liver MDA, TG, TC significantly lower, serum HDL - C, liver SOD, GSH activity increasde. Conclusion ： Electroacupuncture by lowering blood lipids, inhibit oxidation, reduce lipid peroxidation, so that the fatty degeneration of liver tissue injury and inflammation can be improver.